{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T06:10:58Z","timestamp":1790057458268,"version":"4.0.1"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,4,27]],"date-time":"2017-04-27T00:00:00Z","timestamp":1493251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Division of Periodontics"},{"name":"Section of Oral"},{"name":"Diagnostic and Rehabilitation Sciences"},{"name":"Ultrasound Elasticity Imaging Laboratory"},{"name":"Columbia University Medical Center"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>We investigated the cross\u2010sectional relationship between periodontal status and arterial stiffness, assessed through a novel Pulse Wave Imaging methodology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighty volunteers were enrolled (39% male, age range 24\u201378\u00a0years) and 33 pairs were formed of periodontitis patients\/periodontally healthy controls, matched by age and gender. A full\u2010mouth periodontal examination was performed and the degree of stiffness of the right and left carotid arteries was assessed by measuring pulse wave velocity (<jats:styled-content style=\"fixed-case\">PWV<\/jats:styled-content>) and the uniformity in pulse wave propagation (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>). Wilcoxon signed\u2010rank tests for paired observations were used to compare periodontitis patients and healthy controls. Univariate and multivariate analyses were performed to analyze the association between <jats:styled-content style=\"fixed-case\">PWV<\/jats:styled-content> and <jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> and potential explanatory variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with periodontitis had a statistically significantly lower uniformity in wave propagation (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>) than controls (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.01), but <jats:styled-content style=\"fixed-case\">PWV<\/jats:styled-content> did not differ between the two groups. Univariate analysis showed a significant negative association between <jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> and periodontitis, body mass index and smoking; periodontitis remained statistically associated with <jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> in the multivariate analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with periodontitis and no established cardiovascular disease presented with lower degree of uniformity in the transmission of the pulse wave through the carotid arteries, suggesting an association between periodontitis and arterial stiffness\/functional alterations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12717","type":"journal-article","created":{"date-parts":[[2017,3,9]],"date-time":"2017-03-09T19:55:07Z","timestamp":1489089307000},"page":"502-510","source":"Crossref","is-referenced-by-count":7,"title":["Assessment of arterial stiffness in periodontitis using a novel pulse wave imaging 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