{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T21:11:55Z","timestamp":1778706715751,"version":"3.51.4"},"reference-count":46,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,7,26]],"date-time":"2017-07-26T00:00:00Z","timestamp":1501027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"S\u00e3o Paulo Research Foundation (FAPESP, Brazil).","award":["2009\/17677-8"],"award-info":[{"award-number":["2009\/17677-8"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the clinical effects of different dosages of metronidazole (MTZ) and durations of MTZ\u00a0+\u00a0amoxicillin (AMX) in the treatment of generalized chronic periodontitis (GChP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Subjects with severe GChP were randomly assigned to receive scaling and root planing (SRP)\u2010only, or combined with 250 or 400\u00a0mg of MTZ\u00a0+\u00a0AMX (500\u00a0mg) thrice a day (TID), for 7 or 14\u00a0days. Subjects were monitored for 1\u00a0year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and nine subjects were enrolled. At 1 year, 61.9% and 63.6% of the subjects receiving AMX\u00a0+\u00a0250 or 400\u00a0mg of MTZ for 14\u00a0days, respectively, reached the clinical endpoint for treatment (\u22644 sites with probing depth \u22655\u00a0mm), against 31.8% of those taking 250 or 400\u00a0mg of MTZ for 7\u00a0days (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05) and 13.6% of those receiving SRP\u2010only (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05). Fourteen days of MTZ\u00a0+\u00a0AMX was the only significant predictor of subjects reaching the clinical endpoint at 1\u00a0year (OR, 5.26; 95% CI, 2.3\u201312.1, <jats:italic>p<\/jats:italic> = .0000). The frequency of adverse events did not differ among treatment groups (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The adjunctive use of 400 or 250\u00a0mg of MTZ plus 500\u00a0mg of AMX\/TID\/14\u00a0days offers statistically significant and clinically relevant benefits over those achieved with SRP alone in the treatment of severe GChP. The added benefits of the 7\u2010days regimen in this population were less evident. (ClinicalTrials.gov NCT02735395).<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12721","type":"journal-article","created":{"date-parts":[[2017,3,17]],"date-time":"2017-03-17T04:36:58Z","timestamp":1489725418000},"page":"822-832","source":"Crossref","is-referenced-by-count":58,"title":["Different antibiotic protocols in the treatment of severe chronic periodontitis: A 1\u2010year randomized trial"],"prefix":"10.1111","volume":"44","author":[{"given":"Ivan","family":"Borges","sequence":"first","affiliation":[{"name":"Department of Periodontology Dental Research Division Guarulhos University  Guarulhos S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo","family":"Faveri","sequence":"additional","affiliation":[{"name":"Department of Periodontology Dental Research Division Guarulhos University  Guarulhos S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciene 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Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2293-3392","authenticated-orcid":false,"given":"Magda","family":"Feres","sequence":"additional","affiliation":[{"name":"Department of Periodontology Dental Research Division Guarulhos University  Guarulhos S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,7,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051X.2011.01795.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.math.2011.05.006"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.110513"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.080540"},{"key":"e_1_2_8_7_1","first-page":"1","volume-title":"Statistical power analysis for the 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