{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T21:24:21Z","timestamp":1760909061986,"version":"3.37.3"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,5,16]],"date-time":"2017-05-16T00:00:00Z","timestamp":1494892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004571","name":"Minist\u00e8re des Affaires Sociales et de la Sant\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004571","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Soluble <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>163 (<jats:styled-content style=\"fixed-case\">sCD<\/jats:styled-content>163) has been implicated as a new biomarker in inflammatory conditions. The aim of this cross\u2010sectional study was to assess <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>163 levels systemically and locally in patients with chronic periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">sCD<\/jats:styled-content>163 levels were measured by <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content> in serum samples from 70 periodontitis and 70 periodontally healthy subjects, and in saliva samples in a subset of the population. Two gingival biopsies were harvested per subject from 20 periodontitis patients: one from a periodontally affected site, the other from a healthy site, and the relative expression of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>163 <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> was assessed by real\u2010time PCR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum <jats:styled-content style=\"fixed-case\">sCD<\/jats:styled-content>163 was significantly higher in periodontitis patients compared to periodontally healthy subjects (720.0\u00a0\u00b1\u00a0330.6\u00a0ng\/<jats:styled-content style=\"fixed-case\">ml <\/jats:styled-content><jats:italic>versus<\/jats:italic> 510.7\u00a0\u00b1\u00a0219.6\u00a0ng\/<jats:styled-content style=\"fixed-case\">ml<\/jats:styled-content>, respectively; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). Similarly, <jats:styled-content style=\"fixed-case\">sCD<\/jats:styled-content>163 levels in saliva were significantly increased in periodontitis compared to healthy subjects (3.01\u00a0\u00b1\u00a05.07\u00a0ng\/<jats:styled-content style=\"fixed-case\">ml <\/jats:styled-content><jats:italic>versus<\/jats:italic> 1.98\u00a0\u00b1\u00a04.95\u00a0ng\/<jats:styled-content style=\"fixed-case\">ml<\/jats:styled-content>, respectively; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.009). Serum and saliva <jats:styled-content style=\"fixed-case\">sCD<\/jats:styled-content>163 levels showed a positive correlation (Kendall's tau .27, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.018). Importantly, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>163 gene expression was significantly higher in affected sites compared to unaffected sites in periodontitis patients, with a mean fold upregulation of 9.9 (<jats:styled-content style=\"fixed-case\">STD<\/jats:styled-content>: 15.3, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.010).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings suggest that <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>163 may be involved in the pathogenesis of periodontitis and its link with systemic conditions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12731","type":"journal-article","created":{"date-parts":[[2017,4,17]],"date-time":"2017-04-17T07:52:39Z","timestamp":1492415559000},"page":"585-590","source":"Crossref","is-referenced-by-count":10,"title":["Increased levels of soluble <scp>CD<\/scp>163 in periodontitis patients"],"prefix":"10.1111","volume":"44","author":[{"given":"Laurent","family":"Detzen","sequence":"first","affiliation":[{"name":"Division of Periodontics College of Dental Medicine Columbia University  New York NY USA"},{"name":"Orofacial Pathologies Imaging and Biotherapies Laboratory Faculty of Odontology Paris Descartes University  Montrouge France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven C. 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