{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T17:05:28Z","timestamp":1790442328877,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T00:00:00Z","timestamp":1498176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Cabakoff Foundation","award":["020815"],"award-info":[{"award-number":["020815"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Peri\u2010implantitis is a major health concern, with unclear pathogenesis, and with no accessible animal models. Our aim was to establish a mouse model for peri\u2010implantitis and to investigate mediators of inflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Mice were divided into implanted versus non\u2010implanted groups. Implants were inserted immediately following the extraction of the upper first molar. Four weeks following implantation, implanted and non\u2010implanted mice were challenged with either <jats:italic>Porphyromonas gingivalis<\/jats:italic> or vehicle (eight mice in each subgroup, 32 mice in total). Alveolar bone loss and expression of inflammatory mediators in the soft tissue were assessed 42\u00a0days following infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>Porphyromonas gingivalis<\/jats:italic> infection induced greater bone loss around implants than around teeth. In non\u2010infected animals, the presence of the implant correlated with elevated expression of <jats:italic>Il\u201010, Foxp3<\/jats:italic> and <jats:italic>Rankl\/Opg<\/jats:italic> ratio, while <jats:italic>Tnf\u2010\u03b1<\/jats:italic> levels were decreased relative to tissue around teeth. Six weeks following infection, <jats:italic>Tnf\u2010\u03b1<\/jats:italic> increased significantly while the expression of <jats:italic>Foxp3<\/jats:italic> decreased in the tissue around the implants. No significant differences in anti\u2010 or pro\u2010inflammatory mediators were found around teeth of infected, relative to non\u2010infected mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Oral infection with <jats:italic>P.\u00a0gingivalis<\/jats:italic> of mice with implants induced bone loss and a shift in gingival cytokine expression. This mouse model enables exploration of the pathogenesis of peri\u2010implantitis and testing of novel treatments.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12735","type":"journal-article","created":{"date-parts":[[2017,4,28]],"date-time":"2017-04-28T14:52:44Z","timestamp":1493391164000},"page":"739-748","source":"Crossref","is-referenced-by-count":67,"title":["Oral infection with <i>Porphyromonas gingivalis<\/i> induces peri\u2010implantitis in a murine model: Evaluation of bone loss and the local inflammatory response"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6054-6481","authenticated-orcid":false,"given":"Rinat","family":"Tzach\u2010Nahman","sequence":"first","affiliation":[{"name":"Department of Periodontology Faculty of Dental Medicine The Hebrew University\u2010Hadassah Medical Center  Jerusalem Israel"},{"name":"The Institute of Dental Sciences Faculty of Dental Medicine The Hebrew University\u2010Hadassah Medical Center  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Mizraji","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Dental Medicine The Hebrew University\u2010Hadassah Medical Center  Jerusalem Israel"},{"name":"The Institute of Dental Sciences Faculty of Dental Medicine The Hebrew University\u2010Hadassah Medical Center  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9145-5155","authenticated-orcid":false,"given":"Lior","family":"Shapira","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Dental Medicine The Hebrew University\u2010Hadassah Medical Center  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Nussbaum","sequence":"additional","affiliation":[{"name":"The Institute of Dental Sciences Faculty of Dental Medicine The Hebrew University\u2010Hadassah Medical Center  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asaf","family":"Wilensky","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Dental Medicine The Hebrew University\u2010Hadassah Medical Center  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-015-0031-9"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0b013e318266fb2d"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01672.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.9.1490"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.12.8296"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900378"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12067"},{"key":"e_1_2_7_9_1","first-page":"60","article-title":"Pathogenesis of periodontitis: Role of cytokines in host response","volume":"29","author":"Deo V.","year":"2010","journal-title":"Dentistry Today"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12334"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2008.01680.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12303"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2007.01172.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2011.10.006"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2010.00348.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1999.14.7.1167"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1079490"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1992.030102.x"},{"key":"e_1_2_7_19_1","first-page":"xxiv","volume-title":"Clinical periodontology and implant dentistry","author":"Lindhe J.","year":"2003"},{"key":"e_1_2_7_20_1","volume-title":"Clinical periodontology and implant dentistry","author":"Lindhe J.","year":"2008"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.8.1367"},{"key":"e_1_2_7_22_1","volume-title":"Contemporary implant dentistry","author":"Misch C. 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