{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T15:07:47Z","timestamp":1768921667262,"version":"3.49.0"},"reference-count":47,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T00:00:00Z","timestamp":1498176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2017,7]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>In order to enhance clinical improvement of intrabony defects, the addition of enamel matrix derivatives (EMD<\/jats:styled-content>) to bone substitues (BS<\/jats:styled-content>) has been investigated. The aim of this systematic review is to figure out whether such a combination, in comparison to the treatment with BS<\/jats:styled-content> alone has beneficial effects on the following outcomes: clinical attachment level (CAL<\/jats:styled-content>) gain, probing depth (PD<\/jats:styled-content>) reduction and recession (REC<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>Electronic databases (PUBMED<\/jats:styled-content>, SCOPUS<\/jats:styled-content>, EBSCO<\/jats:styled-content> Host Research Databases and Web of Knowledge) were searched for randomized controlled trials in humans addressing the use of a combination of BS<\/jats:styled-content> and EMD<\/jats:styled-content> versus a control group with BS<\/jats:styled-content> alone for the treatment of intrabony defects, with a minimum of 6\u00a0months of follow\u2010up; meta\u2010analysis and trial sequential analysis were then performed.<\/jats:p><\/jats:sec>Results<\/jats:title>From a total of 1,197 records screened by title and abstract, nine studies were read full\u2010text and five out of them included in the meta\u2010analysis. No significant differences have been demonstrated both for CAL<\/jats:styled-content> gain, PD<\/jats:styled-content> reduction and REC<\/jats:styled-content> between test and control groups.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>In the treatment of intrabony defects, the addition of EMD<\/jats:styled-content> to BS<\/jats:styled-content> seems to be not beneficial in terms of CAL<\/jats:styled-content> gain, PD<\/jats:styled-content> reduction and REC<\/jats:styled-content> changes. However, such results should be considered with caution because of the small number of studies included in the meta\u2010analysis and their heterogeneity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12742","type":"journal-article","created":{"date-parts":[[2017,5,6]],"date-time":"2017-05-06T07:26:39Z","timestamp":1494055599000},"page":"729-738","source":"Crossref","is-referenced-by-count":25,"title":["Addition of enamel matrix derivatives to bone substitutes for the treatment of intrabony defects: A systematic review, meta\u2010analysis and trial sequential analysis"],"prefix":"10.1111","volume":"44","author":[{"given":"Giuseppe","family":"Troiano","sequence":"first","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Foggia Foggia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Laino","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Foggia Foggia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khrystyna","family":"Zhurakivska","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Foggia Foggia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Cicci\u00f9","sequence":"additional","affiliation":[{"name":"Department of Human Pathology School of Dentistry University of Messina Messina Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Lo Muzio","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Foggia Foggia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucio","family":"Lo Russo","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Foggia Foggia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,6,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-009-0369-y"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1989.60.12.647"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1989.60.12.675"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2007.10.007"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyn188"},{"key":"e_1_2_8_7_1","first-page":"589","article-title":"The simplified papilla preservation flap. 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