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Periodontal disease in na\u00efve or arthritic mice was induced by oral infection with\n                      <jats:italic>P. gingivalis<\/jats:italic>\n                      . Animals were sacrificed 7, 15 and 30\u00a0days after infection. Alveolar bone loss, joint histopathology, articular hyperalgesia and joint cytokine production were assessed, in addition to the proportion of Th17 and Treg cells isolated from the inguinal lymph nodes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      No influence of experimentally\u2010induced arthritis was found on the alveolar bone resorption induced by\n                      <jats:italic>P. gingivalis<\/jats:italic>\n                      . However\n                      <jats:italic>,<\/jats:italic>\n                      mice with experimentally\u2010induced arthritis that were exposed to\n                      <jats:italic>P. gingivalis<\/jats:italic>\n                      presented higher joint damage and Th17 frequencies when compared to non\u2010infected mice. The aggravation of arthritis by periodontitis was accompanied by increased\n                      <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                      \u201017 production and articular neutrophil infiltration, whereas arthritis aggravation and changes in neutrophil infiltration were absent in\n                      <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                      \u201017\n                      <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>\n                      \u2010deficient mice.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The effects of\n                      <jats:italic>P. gingivalis\u2010<\/jats:italic>\n                      induced periodontitis on arthritis are dependent on Th17 expansion and\n                      <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                      \u201017\n                      <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>\n                      signalling, which lead to increased neutrophil infiltration into the joints.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.12743","type":"journal-article","created":{"date-parts":[[2017,5,12]],"date-time":"2017-05-12T11:32:55Z","timestamp":1494588775000},"page":"881-891","source":"Crossref","is-referenced-by-count":38,"title":["The aggravation of arthritis by periodontitis is dependent of\n                    <scp>IL<\/scp>\n                    \u201017 receptor A activation"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3988-1939","authenticated-orcid":false,"given":"Sabrina G.","family":"de Aquino","sequence":"first","affiliation":[{"name":"Department of Diagnosis and Oral Surgery School of Dentistry at Araraquara Univ. Estadual Paulista \u2010 UNESP  Araraquara Brazil"},{"name":"Department of Clinical and Social Dentistry Health Science Center Federal University of Para\u00edba  Jo\u00e3o Pessoa Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jhimmy","family":"Talbot","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Medicine of Ribeirao Preto University of Sao Paulo  Ribeir\u00e3o Preto Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiane","family":"S\u00f4nego","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Medicine of Ribeirao Preto University of Sao Paulo  Ribeir\u00e3o Preto Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter M.","family":"Turato","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Medicine of Ribeirao Preto University of Sao Paulo  Ribeir\u00e3o Preto Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Grespan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Medicine of Ribeirao Preto University of Sao Paulo  Ribeir\u00e3o Preto Brazil"},{"name":"Department of Physiology Biological and Health Science Center Federal University of Sergipe  Aracaj\u00fa Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario J.","family":"Avila\u2010Campos","sequence":"additional","affiliation":[{"name":"Department of Microbiology Institute of Biomedical Sciences University of Sao Paulo  Ribeir\u00e3o Preto Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando Q.","family":"Cunha","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Medicine of Ribeirao Preto University of Sao Paulo  Ribeir\u00e3o Preto Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joni A.","family":"Cirelli","sequence":"additional","affiliation":[{"name":"Department of Diagnosis and Oral Surgery School of Dentistry at Araraquara Univ. 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