{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:57:28Z","timestamp":1780621048230,"version":"3.54.1"},"reference-count":47,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,9,11]],"date-time":"2017-09-11T00:00:00Z","timestamp":1505088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["GZ: SCHA 1582\/3\u20101"],"award-info":[{"award-number":["GZ: SCHA 1582\/3\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009947","name":"Merck Sharp and Dohme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009947","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["FKZ 0315540A"],"award-info":[{"award-number":["FKZ 0315540A"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The intronic variant rs4252120 in the plasminogen gene (<jats:italic>PLG<\/jats:italic>) is known to be associated with aggressive periodontitis (AgP) and atherosclerosis. Here, we examined the chromosomal region spanning <jats:italic>PLG<\/jats:italic> for associations with both chronic periodontitis (CP) and AgP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>The association of <jats:italic>PLG<\/jats:italic> candidate rs4252120 was tested in a German case\u2013control sample of 1,419 CP cases using the genotyping assay hCV11225947 and 4,562 controls, genotyped with HumanOmni BeadChips. The German and Dutch sample of AgP cases (<jats:italic>N<\/jats:italic>\u00a0=\u00a0851) and controls (<jats:italic>N<\/jats:italic>\u00a0=\u00a06,836) were genotyped with HumanOmni BeadChips. The North American CP sample (<jats:italic>N<\/jats:italic>\u00a0=\u00a02,681 cases, 1,823 controls) was previously genotyped on the Genome\u2010Wide Human SNP Array 6.0. Genotypes were imputed (software Impute v2), and association tests were performed using an additive genetic model adjusting for sex and smoking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Rs4252120 was not associated with CP. However, a haplotype block downstream of <jats:italic>PLG<\/jats:italic> and not in linkage disequilibrium with rs4252120 (<jats:italic>r<\/jats:italic><jats:sup>2\u00a0<\/jats:sup>=\u00a0.08) was associated with both AgP (rs1247559; <jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.002, odds ratio [OR]\u00a0=\u00a01.33) and CP (<jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.02, OR\u00a0=\u00a01.15). That locus was also significantly associated with <jats:italic>PLG<\/jats:italic> expression in osteoblasts (<jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>6.9\u00a0\u00d7\u00a010<jats:sup>\u22125<\/jats:sup>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings support a role of genetic variants in <jats:italic>PLG<\/jats:italic> in the aetiology of periodontitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12749","type":"journal-article","created":{"date-parts":[[2017,5,26]],"date-time":"2017-05-26T09:52:42Z","timestamp":1495792362000},"page":"962-970","source":"Crossref","is-referenced-by-count":22,"title":["A haplotype block downstream of plasminogen is associated with chronic and aggressive periodontitis"],"prefix":"10.1111","volume":"44","author":[{"given":"Matthias","family":"Munz","sequence":"first","affiliation":[{"name":"Department of Periodontology Institute of Dental, Oral and Maxillary Medicine Charit\u00e9 \u2013 University Medicine Berlin  Berlin Germany"},{"name":"Institute for Integrative and Experimental Genomics University Medical Center Schleswig\u2010Holstein \u2010 Campus L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Periodontology Institute of Dental, Oral and Maxillary Medicine Charit\u00e9 \u2013 University Medicine Berlin  Berlin Germany"},{"name":"Department of Stomatology Zhejiang Provincial People's Hospital  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Jockel\u2010Schneider","sequence":"additional","affiliation":[{"name":"Department of Periodontology Clinic of Preventive Dentistry and Periodontology University Medical Center of the Julius\u2010Maximilians\u2010University  W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Knut","family":"Adam","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry, Periodontology and Preventive Dentistry Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Hoffman","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics University of Bonn  Bonn Germany"},{"name":"Human Genomics Research Group Department of Biomedicine University Hospital of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Berger","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology and Social Medicine University of M\u00fcnster  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Kocher","sequence":"additional","affiliation":[{"name":"Unit of Periodontology Department of Restorative Dentistry, Periodontology, Endodontology, Preventive Dentistry and Pedodontics, Dental School University Medicine Greifswald  Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0495-6926","authenticated-orcid":false,"given":"J\u00f6rg","family":"Meyle","sequence":"additional","affiliation":[{"name":"Department of Periodontology University Medical Center Giessen and Marburg  Gie\u00dfen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1655-8055","authenticated-orcid":false,"given":"Peter","family":"Eickholz","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Centre for Dental, Oral Medicine (Carolinum) Johann Wolfgang Goethe\u2010University  Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christof","family":"Doerfer","sequence":"additional","affiliation":[{"name":"Department of Operative Dentistry and 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Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Schreiber","sequence":"additional","affiliation":[{"name":"Institute of Clinical Molecular Biology Christian\u2010Albrechts\u2010University  Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0727-9441","authenticated-orcid":false,"given":"Steven","family":"Offenbacher","sequence":"additional","affiliation":[{"name":"Department of Periodontology UNC School of Dentistry  Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1290-7251","authenticated-orcid":false,"given":"Kimon","family":"Divaris","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry UNC School of Dentistry  Chapel Hill NC USA"},{"name":"Department of Epidemiology UNC Gillings School of Global Public Health  Chapel Hill NC 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