{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T14:08:21Z","timestamp":1767967701920,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,8,30]],"date-time":"2017-08-30T00:00:00Z","timestamp":1504051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Present clinical practice broadly relies on off\u2010the\u2010shelf allogeneic, xenogeneic or synthetic bone biomaterials in support of sinus augmentation. Also, recombinant human bone morphogenetic protein\u20102 in an absorbable collagen sponge carrier (rhBMP\u20102\/ACS) has been shown to support clinically relevant bone formation when used to augment the maxillary sinus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate local bone formation\/dental implant osseointegration following implantation of two particulate bone biomaterials using the mini\u2010pig sinus augmentation model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Nine adult G\u00f6ttingen mini\u2010pigs were used for evaluation of a biphasic ceramic (15%\/85% HA\/\u00df\u2010TCP) and an allogeneic mineralized bone biomaterial. Treatments randomized to contralateral sinus sites included sham\u2010surgery (control) and biomaterials. Two threaded dental implants (\u00f84.0\u00a0\u00d7\u00a011.5\u00a0mm) were placed at each sinus site. The animals were euthanized at 8\u00a0weeks for histologic analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Execution of the surgical protocol and healing was unremarkable. Limited infraorbital swelling was observed until suture removal. The biphasic ceramic and allogeneic bone biomaterials produced significantly increased bone formation (5.2\u00a0\u00b1\u00a01.9\u00a0mm and 4.9\u00a0\u00b1\u00a01.6\u00a0mm vs. 2.6\u00a0\u00b1\u00a00.5\u00a0mm, <jats:italic>p\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05) and osseointegration (18.0\u00a0\u00b1\u00a06.0% and 25.1\u00a0\u00b1\u00a018.2% vs. 10.1\u00a0\u00b1\u00a08.0%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05) over the sham\u2010surgery control. No significant differences were observed between biomaterials.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Implantation of biphasic ceramic or allogeneic bone biomaterials enhances bone formation in the mini\u2010pig maxillary sinus, however, dental implant bone support is incomplete resulting in overall limited osseointegration.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12766","type":"journal-article","created":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T12:33:00Z","timestamp":1498221180000},"page":"1059-1066","source":"Crossref","is-referenced-by-count":7,"title":["Sinus augmentation using a mini\u2010pig model: Effect of ceramic and allogeneic bone biomaterials"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4092-908X","authenticated-orcid":false,"given":"Cristiano","family":"Susin","sequence":"first","affiliation":[{"name":"Laboratory for Applied Periodontal and Craniofacial Regeneration (LAPCR) Augusta University|Dental College of Georgia  Augusta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5452-3822","authenticated-orcid":false,"given":"Tiago","family":"Fiorini","sequence":"additional","affiliation":[{"name":"Laboratory for Applied Periodontal and Craniofacial Regeneration (LAPCR) Augusta University|Dental College of Georgia  Augusta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaebum","family":"Lee","sequence":"additional","affiliation":[{"name":"Laboratory for Applied Periodontal and Craniofacial Regeneration (LAPCR) Augusta University|Dental College of Georgia  Augusta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4618-3845","authenticated-orcid":false,"given":"Rubens Moreno","family":"de Freitas","sequence":"additional","affiliation":[{"name":"Laboratory for Applied Periodontal and Craniofacial Regeneration (LAPCR) Augusta University|Dental College of Georgia  Augusta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsien\u2010Chung","family":"Chiu","sequence":"additional","affiliation":[{"name":"Laboratory for Applied Periodontal and Craniofacial Regeneration (LAPCR) Augusta University|Dental College of Georgia  Augusta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hari S.","family":"Prasad","sequence":"additional","affiliation":[{"name":"Laboratory for Applied Periodontal and Craniofacial Regeneration (LAPCR) Augusta University|Dental College of Georgia  Augusta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda N.","family":"Buxton","sequence":"additional","affiliation":[{"name":"Laboratory for Applied Periodontal and Craniofacial Regeneration (LAPCR) Augusta University|Dental College of Georgia  Augusta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1607-0583","authenticated-orcid":false,"given":"Ulf M. 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