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Sixty patients were enrolled: 20 healthy controls and 40 patients with periodontitis. The 40 patients were randomized for scaling and root planing (<jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>) or <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content>. Periodontal (plaque index, probing depth, clinical recession, clinical attachment level, bleeding on probing and gingival crevicular fluid volume, corresponding to 381 <jats:italic>versus<\/jats:italic> 428 critical sites), microbiological (<jats:italic>Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, Prevotella intermedia<\/jats:italic> and <jats:italic>Campylobacter rectus<\/jats:italic> presence, 18 <jats:italic>versus<\/jats:italic> 19 samples) and biochemical (interleukin (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>)\u20101\u03b2, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 and tumour necrosis factor (<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>)\u2010\u03b1, receptor activator of nuclear factor\u2010kappaB ligand (<jats:styled-content style=\"fixed-case\">RANK<\/jats:styled-content>\u2010L) and osteoprotegerin (<jats:styled-content style=\"fixed-case\">OPG<\/jats:styled-content>) levels, 18 <jats:italic>versus<\/jats:italic> 19 samples) parameters were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Within each group, significant improvements were found for clinical parameters, though without significant differences between groups. <jats:styled-content style=\"fixed-case\">RANK<\/jats:styled-content>\u2010L was significantly decreased at week 13 in the <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> group compared with the <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content> group. <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content>, but not <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content> alone, significantly reduced the abundance of <jats:italic>A.\u00a0actinomycetemcomitans<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Except for a significant decrease in the pathogenic burden of <jats:italic>A.\u00a0actinomycetemcomitans<\/jats:italic>, coadjuvant <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> resulted in no additional improvement compared with <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content> alone in patients diagnosed with moderate\u2010to\u2010advanced chronic periodontitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12768","type":"journal-article","created":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T07:52:38Z","timestamp":1498895558000},"page":"915-925","source":"Crossref","is-referenced-by-count":53,"title":["Effects of photodynamic therapy in periodontal treatment: A randomized, controlled clinical trial"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6736-5675","authenticated-orcid":false,"given":"Marta","family":"Segarra\u2010Vidal","sequence":"first","affiliation":[{"name":"Department of Stomatology School of Medicine and Dentistry University of Valencia  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sol","family":"Guerra\u2010Ojeda","sequence":"additional","affiliation":[{"name":"Department of Physiology School of Medicine and Dentistry University of Valencia  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilian Soraya","family":"Vall\u00e9s","sequence":"additional","affiliation":[{"name":"Department of Physiology School of Medicine and Dentistry University of Valencia  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9s","family":"L\u00f3pez\u2010Rold\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Stomatology 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