{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:09:44Z","timestamp":1787015384015,"version":"build-2736575974"},"reference-count":44,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,8,30]],"date-time":"2017-08-30T00:00:00Z","timestamp":1504051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008408","name":"H\u00f6gskolan Kristianstad","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008408","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      To evaluate the long\u2010term effects of a zinc acetate and chlorhexidine diacetate mouth rinse (Zn\/\n                      <jats:styled-content style=\"fixed-case\">CHX<\/jats:styled-content>\n                      ) on intra\u2010oral halitosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      Forty\u2010six adults with intra\u2010oral halitosis were randomized into a 6\u2010month, double\u2010blind, placebo\u2010controlled clinical study. The presence of intra\u2010oral halitosis was evaluated at baseline, 3 and 6\u00a0months after treatment by assessment of organoleptic score (\n                      <jats:styled-content style=\"fixed-case\">OLS<\/jats:styled-content>\n                      ) and by total volatile sulphur compounds (T\u2010\n                      <jats:styled-content style=\"fixed-case\">VSC<\/jats:styled-content>\n                      ), hydrogen sulphide (H\n                      <jats:sub>2<\/jats:sub>\n                      S) and methyl mercaptan (\n                      <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content>\n                      ) concentrations in exhaled air.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A Zn\/\n                      <jats:styled-content style=\"fixed-case\">CHX<\/jats:styled-content>\n                      mouth rinse provided significantly better control of intra\u2010oral halitosis than a placebo mouth rinse. At 3 and 6\u00a0months, individuals rinsing with the Zn\/\n                      <jats:styled-content style=\"fixed-case\">CHX<\/jats:styled-content>\n                      rinse presented with reductions of the\n                      <jats:styled-content style=\"fixed-case\">OLS<\/jats:styled-content>\n                      , T\u2010\n                      <jats:styled-content style=\"fixed-case\">VSC<\/jats:styled-content>\n                      (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\n                      <jats:italic>\u00a0<\/jats:italic>\n                      .01, respectively), H\n                      <jats:sub>2<\/jats:sub>\n                      S (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\n                      <jats:italic>\u00a0<\/jats:italic>\n                      .001), and\n                      <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content>\n                      (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\n                      <jats:italic>\u00a0<\/jats:italic>\n                      .01) in subjects\u2019 exhaled air. At 6\u00a0months, 68.2% of individuals using the Zn\/\n                      <jats:styled-content style=\"fixed-case\">CHX<\/jats:styled-content>\n                      rinse experienced a 1 or 2 category improvement in\n                      <jats:styled-content style=\"fixed-case\">OLS<\/jats:styled-content>\n                      compared with 19.1% of placebo\u2010treated subjects. 91% of subjects in the Zn\/\n                      <jats:styled-content style=\"fixed-case\">CHX<\/jats:styled-content>\n                      group were categorized as being effectively treated for intra\u2010oral halitosis (i.e. H\n                      <jats:sub>2<\/jats:sub>\n                      S\u00a0&lt;\u00a0112\u00a0ppb), compared to 43% in the placebo group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Zn\/\n                      <jats:styled-content style=\"fixed-case\">CHX<\/jats:styled-content>\n                      mouth rinse provides effective long\u2010term efficacy against intra\u2010oral halitosis, assessed both objectively and subjectively. With regular rinsing, the effect was sustained for 6\u00a0months.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.12779","type":"journal-article","created":{"date-parts":[[2017,7,20]],"date-time":"2017-07-20T08:52:36Z","timestamp":1500540756000},"page":"1010-1019","source":"Crossref","is-referenced-by-count":14,"title":["The long\u2010term effect of a zinc acetate and chlorhexidine diacetate containing mouth rinse on intra\u2010oral halitosis\u2014A randomized clinical trial"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5755-3998","authenticated-orcid":false,"given":"Seida","family":"Erovic Ademovski","sequence":"first","affiliation":[{"name":"School for Health and Society Kristianstad University  Kristianstad Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carina","family":"M\u00e5rtensson","sequence":"additional","affiliation":[{"name":"School for Health and Society Kristianstad 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