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These reactions are of limited specificity and exhaust without providing long\u2010term protection. Functional fluids and effector molecules contribute to the defence against infectious agents, drive the immune response, and direct the cellular players.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To review the literature and present a summary of current knowledge about the function of tissues, cellular players and soluble mediators of innate immunity relevant to caries and periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Historical and recent literature was critically reviewed based on publications in peer\u2010reviewed scientific journals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The innate immune response is vital to resistance against caries and periodontitis and rapidly attempts to protect against infectious agents in the dental hard and soft tissues. Soluble mediators include specialized proteins and lipids. They function to signal to immune and inflammatory cells, provide antimicrobial resistance, and also induce mechanisms for potential repair of damaged tissues.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Far less investigated than adaptive immunity, innate immune responses are an emerging scientific and therapeutic frontier. Soluble mediators of the innate response provide a network of signals to organize the near immediate molecular and cellular response to infection, including direct and immediate antimicrobial activity. Further studies in human disease and animal models are generally needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12781","type":"journal-article","created":{"date-parts":[[2017,7,20]],"date-time":"2017-07-20T13:14:35Z","timestamp":1500556475000},"page":"1215-1225","source":"Crossref","is-referenced-by-count":102,"title":["The innate host response in caries and periodontitis"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0495-6926","authenticated-orcid":false,"given":"Joerg","family":"Meyle","sequence":"first","affiliation":[{"name":"Department of Periodontology University of Giessen  Giessen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Dommisch","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Synoptic Dentistry Charit\u00e9 \u2013 Medical University Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Groeger","sequence":"additional","affiliation":[{"name":"Department of Periodontology University of Giessen  Giessen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo A.","family":"Giacaman","sequence":"additional","affiliation":[{"name":"Cariology Unit Department of Oral Rehabilitation and Interdisciplinary Excellence Research Program on Healthy Aging (PIEIES) University of Talca  Talca Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Costalonga","sequence":"additional","affiliation":[{"name":"Department of Developmental and Surgical Sciences University of Minnesota  Minneapolis MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Herzberg","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Biological Sciences University of Minnesota  Minneapolis MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753425915617521"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01752.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.5005\/jcdp-9-3-72"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1116770109"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.11.020"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0447.2002.21236.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2013.07.007"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/32588"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.2008.00448.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/10520295.2013.832800"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2007.03.001"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.2011.00863.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.1.342-351.2005"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2004.11.008"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micres.2015.05.008"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1502693"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0081665"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1590\/1807-3107BOR-2016.vol30.0052"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1092385"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345930720031001"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.3MR1114-556R"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.2008.00463.x"},{"key":"e_1_2_8_24_1","first-page":"178","article-title":"Salivary protein characteristics from saliva of carious lesionfree and high caries adults","volume":"29","author":"Castro R. 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