{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:06:56Z","timestamp":1790842016331,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,9,22]],"date-time":"2017-09-22T00:00:00Z","timestamp":1506038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100002002","name":"Cancer Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006070","name":"Society of Surgical Oncology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006070","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess long\u2010term attachment and periodontitis\u2010related tooth loss (PTL) in untreated periodontal disease over 40\u00a0years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>Data originated from the natural history of periodontitis study in Sri Lankan tea labourers first examined in 1970. In 2010, 75 subjects (15.6%) of the original cohort were re\u2010examined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      PTL over 40\u00a0years varied between 0 and 28 teeth (mean 13.1). Four subjects presented with no PTL, while 12 were edentulous. Logistic regression revealed attachment loss as a statistically significant covariate for PTL (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.004). Markov chain analysis showed that smoking and calculus were associated with disease initiation and that calculus, plaque, and gingivitis were associated with loss of attachment and progression to advanced disease. Mean attachment loss &lt;1.81\u00a0mm at the age of 30 yielded highest sensitivity and specificity (0.71) to allocate subjects into a cohort with a dentition of at least 20 teeth at 60\u00a0years of age.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results highlight the importance of treating early periodontitis along with smoking cessation, in those under 30\u00a0years of age. They further show that calculus removal, plaque control, and the control of gingivitis are essential in preventing disease progression, further loss of attachment and ultimately tooth loss.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.12782","type":"journal-article","created":{"date-parts":[[2017,7,22]],"date-time":"2017-07-22T04:56:34Z","timestamp":1500699394000},"page":"1182-1191","source":"Crossref","is-referenced-by-count":233,"title":["Natural history of periodontitis: Disease progression and tooth loss over 40\u00a0years"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5110-2539","authenticated-orcid":false,"given":"Christoph A.","family":"Ramseier","sequence":"first","affiliation":[{"name":"University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Age","family":"Anerud","sequence":"additional","affiliation":[{"name":"The University of Honk Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Dulac","sequence":"additional","affiliation":[{"name":"The University of Honk Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Lulic","sequence":"additional","affiliation":[{"name":"The University of Honk Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary P.","family":"Cullinan","sequence":"additional","affiliation":[{"name":"The University of Queensland  Brisbane QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory J.","family":"Seymour","sequence":"additional","affiliation":[{"name":"The University of Queensland  Brisbane QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malcolm J.","family":"Faddy","sequence":"additional","affiliation":[{"name":"Queensland University of Technology  Brisbane QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"B\u00fcrgin","sequence":"additional","affiliation":[{"name":"University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Sch\u00e4tzle","sequence":"additional","affiliation":[{"name":"University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklaus P.","family":"Lang","sequence":"additional","affiliation":[{"name":"University of Bern  Bern Switzerland"},{"name":"The University of Honk Kong  Hong Kong China"},{"name":"University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1997.68.11.1033"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.3.454"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345000790071501"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1967.tb01887.x"},{"key":"e_1_2_8_6_1","unstructured":"Harris K. 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