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The present systematic review, meta\u2010analysis and meta\u2010regression studies focused on investigating whether serum lipid parameter levels were elevated in patients with periodontal disease (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>; without altered systemic conditions) in comparison with periodontally healthy subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Eligible studies were those with data about serum lipid parameter levels in non\u2010smoking subjects with and without chronic periodontitis, who are generally healthy and not taking any medication for dyslipidaemia. Mean differences and 95% confidence intervals for total cholesterol, triglycerides, low\u2010density lipoprotein (<jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content>) cholesterol and high\u2010density lipoprotein (<jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content>) cholesterol were obtained from all the selected studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 19 publications were included for meta\u2010analysis. Participants with chronic periodontitis presented significantly higher serum levels of <jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content> and triglycerides (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.003 and <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.0001, respectively). The total cholesterol was higher in the <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> group, but without significant difference in comparison with healthy participants. Significantly (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.0005) lower <jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content> serum levels were found in patients with chronic periodontitis than in healthy subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Even considering the limitations of this meta\u2010analysis, it is suggested that <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> is significantly associated with reduction in <jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content> and elevation of <jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content> and triglyceride concentrations. This analysis supports the rationale that periodontal disease is associated with lipid metabolic control.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12792","type":"journal-article","created":{"date-parts":[[2017,8,7]],"date-time":"2017-08-07T07:52:38Z","timestamp":1502092358000},"page":"1192-1207","source":"Crossref","is-referenced-by-count":96,"title":["Serum lipid levels in patients with periodontal disease: A meta\u2010analysis and meta\u2010regression"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3120-0617","authenticated-orcid":false,"given":"Rafael","family":"Nepomuceno","sequence":"first","affiliation":[{"name":"Department of Diagnosis and Surgery School of Dentistry at Araraquara S\u00e3o Paulo State University \u2013 UNESP  Araraquara SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzane C.","family":"Pigossi","sequence":"additional","affiliation":[{"name":"Department of Diagnosis and Surgery School of Dentistry at Araraquara S\u00e3o Paulo State University \u2013 UNESP  Araraquara SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livia S.","family":"Finoti","sequence":"additional","affiliation":[{"name":"Department of Periodontics University of Pennsylvania School of Dental Medicine  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana R. 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