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Following active treatment, patients received biannual maintenance; 161 patients completed the five\u2010year follow\u2010up maintenance and examination, where clinical attachment level (CAL), probing pocket depth (PPD), presence of plaque and bleeding were registered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Metronidazole increased the highest CAL recording statistically insignificantly by an average of 0.17\u00a0mm while FDIS decreased it by an average of 0.12\u00a0mm. The corresponding values for the highest PPD were 0.00 and 0.05\u00a0mm, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>While single\u2010level analyses showed statistically significant differences, they could not be confirmed with more appropriate analyses and were too small to recommend MTZ, with its risk of patient side effects and environmental consequences, for the treatment of patients with severe periodontitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12793","type":"journal-article","created":{"date-parts":[[2017,8,10]],"date-time":"2017-08-10T16:22:39Z","timestamp":1502382159000},"page":"1029-1038","source":"Crossref","is-referenced-by-count":23,"title":["A double\u2010masked Randomized Clinical Trial (<scp>RCT<\/scp>) comparing four periodontitis treatment strategies: 5\u2010year clinical results"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6516-6621","authenticated-orcid":false,"given":"Hans R.","family":"Preus","sequence":"first","affiliation":[{"name":"Department of Periodontology Institute of Clinical Odontology Faculty of Dentistry University of Oslo  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per","family":"Gjermo","sequence":"additional","affiliation":[{"name":"Department of Periodontology Institute of Clinical Odontology Faculty of Dentistry University of Oslo  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vibeke","family":"Baelum","sequence":"additional","affiliation":[{"name":"Department of Dentistry and Oral Health Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1992.63.8.690"},{"key":"e_1_2_6_3_1","first-page":"456","volume-title":"Practical statistics for medical research","author":"Altman D.G","year":"1991"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303-6979.2004.00433.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1515\/dmdi-2012-0003"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1977.tb02271.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2004.00605.x"},{"key":"e_1_2_6_8_1","unstructured":"CDC. 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