{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:10:37Z","timestamp":1787015437593,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,10,19]],"date-time":"2017-10-19T00:00:00Z","timestamp":1508371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001827","name":"Universiteit van Amsterdam","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001827","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To identify phenotypes of periodontitis patients by the use of an unsupervised modelling technique (clustering), based on pre\u2010treatment radiographic and microbiological characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>This retrospective study included data from 392 untreated periodontitis patients. Co\u2010regularized spectral clustering algorithm was used to cluster the patients. The resulting clusters were subsequently characterized based on their demographics, radiographic bone loss patterns and microbial data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The vast majority of patients fitted into one of the three main clusters (accuracy 90%). Cluster A (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a018) was characterized by high prevalence and high proportions of\n                      <jats:italic>Aggregatibacter actinomycetemcomitans<\/jats:italic>\n                      , a trend for a more localized pattern of alveolar bone loss and young individuals. Clusters B (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0200) and C (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0135) differed clearly in disease severity patterns and smoking habits, but not in microbiological characteristics.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>On the basis of alveolar bone loss patterns and microbiological data, untreated periodontitis patients can be clustered into at least three phenotypes. These results should be validated in other cohorts, and the clinical utility needs to be explored on the basis of periodontal treatment outcomes and\/or disease progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.12797","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T10:32:39Z","timestamp":1502447559000},"page":"1068-1076","source":"Crossref","is-referenced-by-count":13,"title":["At least three phenotypes exist among periodontitis patients"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8267-8987","authenticated-orcid":false,"given":"Chryssa","family":"Delatola","sequence":"first","affiliation":[{"name":"Department of Periodontology Academic Center for Dentistry Amsterdam (ACTA) University of Amsterdam and Vrije Universiteit Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno G.","family":"Loos","sequence":"additional","affiliation":[{"name":"Department of Periodontology Academic Center for Dentistry Amsterdam (ACTA) University of Amsterdam and Vrije Universiteit Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgeni","family":"Levin","sequence":"additional","affiliation":[{"name":"Academic Medical Center (AMC) University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marja L.","family":"Laine","sequence":"additional","affiliation":[{"name":"Department of Periodontology Academic Center for Dentistry Amsterdam (ACTA) University of Amsterdam and Vrije Universiteit Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,19]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"American Academy of Periodontology. 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