{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:16:35Z","timestamp":1790126195295,"version":"4.0.1"},"reference-count":38,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,9,15]],"date-time":"2017-09-15T00:00:00Z","timestamp":1505433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004368","name":"Colgate-Palmolive Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004368","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aims of this study were to; 1) test susceptibility to bacteremia in subjects with moderate gingivitis, and 2) compare the effects of brushing with a fluoride toothpaste (control) as compared to a triclosan\/copolymer toothpaste (test) on those susceptible to repeated bacteremia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>One hundred and seven adult subjects were tested for repeated bacteremia after eating a hard apple. Twenty\u2010nine bacteremia positive subjects were enrolled in a double\u2010blind cross\u2010over study designed to analyse the effects of a test toothpaste. After random toothpaste assignment, subjects brushed for 21\u00a0days. Following a wash\u2010out period, subjects completed the study with the alternate toothpaste. Statistical analysis compared bacteremia between groups by analysis of covariance (<jats:styled-content style=\"fixed-case\">ANCOVA<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010six adult subjects completed the cross\u2010over study. No statistically significant differences for bacteremia were seen at baseline. Mean bacterial counts at baseline and post\u2010treatment visits were 45.5 and 10.8 counts <jats:italic>versus<\/jats:italic> 48.5 and 38.0 counts, respectively (test vs. control group; significant at <jats:italic>p\u00a0<\/jats:italic>&lt;\u00a0.05). Significant reductions in blood borne bacteria were seen in the test <jats:italic>versus<\/jats:italic> control groups in both cultural and <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> data (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Thirty percentage of subjects showed repeated bacteremia. Brushing with a triclosan\/copolymer dentifrice demonstrated significant reductions in bacteremia as compared to the control toothpaste.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12798","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T15:16:38Z","timestamp":1502464598000},"page":"1020-1028","source":"Crossref","is-referenced-by-count":10,"title":["Reduction in bacteremia after brushing with a triclosan\/copolymer dentifrice\u2014A randomized clinical study"],"prefix":"10.1111","volume":"44","author":[{"given":"Prem K.","family":"Sreenivasan","sequence":"first","affiliation":[{"name":"Colgate\u2010Palmolive Company  Piscataway NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Tischio\u2010Bereski","sequence":"additional","affiliation":[{"name":"Oral Biology Department Rutgers School of Dental Medicine Rutgers University  Newark NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6242-6451","authenticated-orcid":false,"given":"Daniel H.","family":"Fine","sequence":"additional","affiliation":[{"name":"Oral Biology Department Rutgers School of Dental Medicine Rutgers University  Newark NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-31248-4_4"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.2009.669"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cden.2015.06.007"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2008.00273.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(54)90071-7"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01372.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.2.210"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a010090"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01599.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00729-13"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2012.01938.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.00924.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12520"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.10.1554"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871529X15666150108115241"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12484"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrtlng.2010.04.009"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753425908095130"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034510375281"},{"key":"e_1_2_8_21_1","first-page":"832","volume-title":"Dental microbiology","author":"Kilian M.","year":"1982"},{"key":"e_1_2_8_22_1","volume-title":"SAS for mixed models","author":"Littell R. 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