{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:24:30Z","timestamp":1790144670186,"version":"4.0.1"},"reference-count":44,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,11,17]],"date-time":"2017-11-17T00:00:00Z","timestamp":1510876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007619","name":"Osteology Foundation","doi-asserted-by":"publisher","award":["14\u2010126"],"award-info":[{"award-number":["14\u2010126"]}],"id":[{"id":"10.13039\/501100007619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Tumour necrosis factor (<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>)\u2010\u03b1 is a pathological factor causing the characteristic symptoms of periodontal disease and rheumatoid arthritis. In this study, we describe the phenotypes of human <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 transgenic mice (<jats:styled-content style=\"fixed-case\">hTNF<\/jats:styled-content>tg) with respect to their periodontium and the temporomandibular joint (<jats:styled-content style=\"fixed-case\">TMJ<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Periodontal structures, <jats:styled-content style=\"fixed-case\">TMJ<\/jats:styled-content> and skull shape of <jats:styled-content style=\"fixed-case\">hTNF<\/jats:styled-content>tg mice and wild\u2010type (<jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content>) littermates were assessed by microcomputed tomography, automated segmentation, geometric morphometrics and histologic ground sections.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We show that <jats:styled-content style=\"fixed-case\">hTNF<\/jats:styled-content>tg mice have an eroded lamina dura and reduced periodontal ligament space compared to (<jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content>) littermates. Transgenic mice further exhibit severe destruction of the <jats:styled-content style=\"fixed-case\">TMJ<\/jats:styled-content>. Geometric morphometrics revealed that <jats:styled-content style=\"fixed-case\">hTNF<\/jats:styled-content>tg mice have a more laterally positioned <jats:styled-content style=\"fixed-case\">TMJ<\/jats:styled-content> with a concomitantly enlarged zygomatic process. Mandibular and maxillary teeth occluded properly.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings suggest that chronic inflammation in <jats:styled-content style=\"fixed-case\">hTNF<\/jats:styled-content>tg mice causes destructive changes of the periodontium and the <jats:styled-content style=\"fixed-case\">TMJ<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12799","type":"journal-article","created":{"date-parts":[[2017,8,18]],"date-time":"2017-08-18T14:52:49Z","timestamp":1503067969000},"page":"1226-1235","source":"Crossref","is-referenced-by-count":14,"title":["Impaired periodontium and temporomandibular joints in tumour necrosis factor\u2010\u03b1 transgenic mice"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0152-9419","authenticated-orcid":false,"given":"Toni","family":"Dobsak","sequence":"first","affiliation":[{"name":"Core Facility Hard Tissue and Biomaterial Research Karl Donath Laboratory School of Dentistry Medical University of Vienna  Vienna Austria"},{"name":"Austrian Cluster for Tissue Regeneration  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2499-325X","authenticated-orcid":false,"given":"Patrick","family":"Heimel","sequence":"additional","affiliation":[{"name":"Core Facility Hard Tissue and Biomaterial Research Karl Donath Laboratory School of Dentistry Medical University of Vienna  Vienna Austria"},{"name":"Austrian Cluster for Tissue Regeneration  Vienna Austria"},{"name":"Ludwig Boltzmann Institute for Experimental and Clinical Traumatology  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9023-4745","authenticated-orcid":false,"given":"Stefan","family":"Tangl","sequence":"additional","affiliation":[{"name":"Core Facility Hard Tissue and Biomaterial Research Karl Donath Laboratory School of Dentistry Medical University of Vienna  Vienna Austria"},{"name":"Austrian Cluster for Tissue Regeneration  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8954-0024","authenticated-orcid":false,"given":"Uwe Y.","family":"Schwarze","sequence":"additional","affiliation":[{"name":"Austrian Cluster for Tissue Regeneration  Vienna Austria"},{"name":"Department of Oral Biology School of Dentistry Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8740-9615","authenticated-orcid":false,"given":"Georg","family":"Schett","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 3 Friedrich Alexander University of Erlangen\u2010 Nuremberg  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5400-9009","authenticated-orcid":false,"given":"Reinhard","family":"Gruber","sequence":"additional","affiliation":[{"name":"Austrian Cluster for Tissue Regeneration  Vienna Austria"},{"name":"Department of Oral Biology School of Dentistry Medical University of Vienna  Vienna Austria"},{"name":"Department of Periodontology School of Dental Medicine University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1400970"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016357.2014.994561"},{"key":"e_1_2_8_4_1","article-title":"The effects of tumour necrosis factor\u2010alpha on bone cells involved in periodontal alveolar bone loss; 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