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Because periodontitis elicits low\u2010grade inflammation, we hypothesized that it could contribute to\n                      <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content>\n                      occurrence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To investigate epidemiologic associations between periodontitis and the incidence of\n                      <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content>\n                      among 2,623 participants of the Study of Health in Pomerania.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Periodontitis at baseline was defined as the percentage of sites (0%, &lt;30%, \u226530%) with (i) clinical attachment level (\n                      <jats:styled-content style=\"fixed-case\">CAL<\/jats:styled-content>\n                      ) \u22653\u00a0mm; (ii) probing pocket depth (\n                      <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\n                      ) \u22654\u00a0mm. Incident\n                      <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content>\n                      was defined as a significant increase in liver echogenicity on ultrasound relative to the kidneys, with the diaphragm indistinct or the echogenic walls of the portal veins invisible.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After a median 7.7\u00a0years of follow\u2010up, 605 incident\n                      <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content>\n                      cases occurred at a rate of 32.5 cases per 1,000 person\u2010years. Relative to participants without\n                      <jats:styled-content style=\"fixed-case\">CAL<\/jats:styled-content>\n                      \u22653\u00a0mm,\n                      <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content>\n                      incidence was elevated slightly in participants with &lt;30% of sites affected and moderately in participants with \u226530% of sites affected (multivariable\u2010adjusted incidence rate ratio\u00a0=\u00a01.28, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      , 0.84, 1.95 and 1.60, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      , 1.05\u20132.43), respectively. A similar dose\u2013response relationship was not observed for\n                      <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      History of periodontitis may be a risk factor for\n                      <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.12800","type":"journal-article","created":{"date-parts":[[2017,8,14]],"date-time":"2017-08-14T04:43:04Z","timestamp":1502685784000},"page":"1077-1087","source":"Crossref","is-referenced-by-count":80,"title":["Periodontitis and Non\u2010alcoholic Fatty Liver Disease, a population\u2010based cohort investigation in the Study of Health in Pomerania"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1207-9732","authenticated-orcid":false,"given":"Aderonke A.","family":"Akinkugbe","sequence":"first","affiliation":[{"name":"Department of Epidemiology University of North Carolina at Chapel Hill  Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary D.","family":"Slade","sequence":"additional","affiliation":[{"name":"Department of Dental Ecology University of North Carolina at Chapel Hill  Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Sidney","family":"Barritt","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology University of North Carolina at Chapel Hill  Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen R.","family":"Cole","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of North Carolina at Chapel Hill  Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0727-9441","authenticated-orcid":false,"given":"Steven","family":"Offenbacher","sequence":"additional","affiliation":[{"name":"Department of Periodontology University of North Carolina at Chapel Hill  Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid","family":"Petersmann","sequence":"additional","affiliation":[{"name":"Institute of Clinical Chemistry and Laboratory Medicine University Medicine Greifswald  Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Kocher","sequence":"additional","affiliation":[{"name":"Unit of Periodontology Department of Restorative Dentistry Periodontology, Endodontology, and Preventive and Pediatric Dentistry University Medicine Greifswald  Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus M.","family":"Lerch","sequence":"additional","affiliation":[{"name":"Department of Medicine A University Medicine Greifswald  Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Mayerle","sequence":"additional","affiliation":[{"name":"Department of Medicine Ludwig\u2010Maximilians University  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"V\u00f6lzke","sequence":"additional","affiliation":[{"name":"Institute for Community Medicine University Medicine Greifswald  Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerardo","family":"Heiss","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of North Carolina at Chapel Hill  Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birte","family":"Holtfreter","sequence":"additional","affiliation":[{"name":"Unit of Periodontology Department of Restorative Dentistry Periodontology, Endodontology, and Preventive and Pediatric Dentistry University Medicine Greifswald  Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.04.014"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra011775"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep04828"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.10.024"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0528.2000.280101.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20734"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200411000-00002"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01571.x"},{"key":"e_1_2_8_10_1","volume-title":"Dentistry, dental practice and the community","author":"Burt B. 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