{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T17:04:15Z","timestamp":1790442255016,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,9,21]],"date-time":"2017-09-21T00:00:00Z","timestamp":1505952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Dentium"},{"name":"University Complutense of Madrid"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To determine the histological outcomes when using a highly porous synthetic bone substitute and a cross\u2010linked collagen membrane for lateral bone augmentation of peri\u2010implant dehiscence defects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In eight dogs, three treatment groups were randomly allocated at each peri\u2010implant dehiscence defect (mean height\u00a0\u00d7\u00a0depth\u00a0=\u00a03\u00a0\u00d7\u00a01\u00a0mm) as follows: (i) synthetic bone substitute covered by a cross\u2010linked collagen membrane (test group), (ii) deproteinized bovine bone mineral covered by a natural collagen membrane (positive control), and (iii) no treatment (negative control). Two healing periods (8 and 16\u00a0weeks) were applied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The differences in healing outcomes between the test and positive control groups were not significant at 8\u00a0weeks. Horizontal bone augmentation 2\u00a0mm below the implant shoulder was significantly greater in the test group (1.22\u00a0\u00b1\u00a00.53\u00a0mm) than in the positive and negative controls (0.42\u00a0\u00b1\u00a00.51 and 0.36\u00a0\u00b1\u00a00.50\u00a0mm, respectively) at 16\u00a0weeks. Similarly, the augmented tissue thickness at 0, 1, and 2\u00a0mm apical to the implant shoulder was significantly greater in the test group than in the positive control group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The test group showed significantly better histological outcomes for lateral bone augmentation and tissue thickness at 16\u00a0weeks compared to both the positive and negative control groups.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.12802","type":"journal-article","created":{"date-parts":[[2017,8,17]],"date-time":"2017-08-17T03:58:06Z","timestamp":1502942286000},"page":"1172-1180","source":"Crossref","is-referenced-by-count":29,"title":["Simultaneous lateral bone augmentation and implant placement using a particulated synthetic bone substitute around chronic peri\u2010implant dehiscence defects in dogs"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6371-4172","authenticated-orcid":false,"given":"Ui\u2010Won","family":"Jung","sequence":"first","affiliation":[{"name":"Department of Periodontology Research Institute for Periodontal Regeneration College of Dentistry Yonsei University  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae\u2010Kook","family":"Cha","sequence":"additional","affiliation":[{"name":"Department of Periodontology Research Institute for Periodontal Regeneration College of Dentistry Yonsei University  Seoul South Korea"},{"name":"Faculty of Odontology Department of Periodontology University Complutense of Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4574-3671","authenticated-orcid":false,"given":"Fabio","family":"Vignoletti","sequence":"additional","affiliation":[{"name":"Faculty of Odontology Department of Periodontology University Complutense of Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9361-3273","authenticated-orcid":false,"given":"Javier","family":"Nu\u00f1ez","sequence":"additional","affiliation":[{"name":"Faculty of Odontology Department of Periodontology University Complutense of Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Sanz","sequence":"additional","affiliation":[{"name":"Faculty of Odontology Department of Periodontology University Complutense of Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariano","family":"Sanz","sequence":"additional","affiliation":[{"name":"Faculty of Odontology Department of Periodontology University Complutense of Madrid  Madrid 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