{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T20:09:05Z","timestamp":1788206945815,"version":"build-2803163510"},"reference-count":18,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,11,10]],"date-time":"2017-11-10T00:00:00Z","timestamp":1510272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["VR: 2016\u201001571"],"award-info":[{"award-number":["VR: 2016\u201001571"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study reports on the 3\u2010year follow\u2010up of patients enrolled in a randomized controlled clinical trial on surgical treatment of advanced peri\u2010implantitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>A total of 100 patients with advanced peri\u2010implantitis were randomly assigned to one of four treatment groups. Surgical therapy aiming at pocket elimination was performed and, in three test groups, supplemented by either systemic antibiotics, use of an antiseptic agent for implant surface decontamination or both. Outcomes were evaluated after 1 and 3\u00a0years by means of clinical and radiological examinations. Differences between groups were explored by regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Clinical examinations at 3\u00a0years after treatment revealed (i) improved peri\u2010implant soft tissue health with a mean reduction in probing depth of 2.7\u00a0mm and a reduction in bleeding\/suppuration on probing of 40% and (ii) stable peri\u2010implant marginal bone levels (mean bone loss during follow\u2010up: 0.04\u00a0mm). Implant surface characteristics had a significant impact on 3\u2010year outcomes, in favour of implants with non\u2010modified surfaces. Benefits of systemic antibiotics were limited to implants with modified surfaces and to the first year of follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>It is suggested that surgical treatment of peri\u2010implantitis is effective and that outcomes of therapy are affected by implant surface characteristics. Potential benefits of systemic antibiotics are not sustained over 3\u00a0years.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12813","type":"journal-article","created":{"date-parts":[[2017,9,13]],"date-time":"2017-09-13T15:38:41Z","timestamp":1505317121000},"page":"1294-1303","source":"Crossref","is-referenced-by-count":186,"title":["Surgical treatment of peri\u2010implantitis: 3\u2010year results from a randomized controlled clinical trial"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8084-3873","authenticated-orcid":false,"given":"Olivier","family":"Carcuac","sequence":"first","affiliation":[{"name":"Department of Periodontology Institute of Odontology The Sahlgrenska Academy at University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1133-6074","authenticated-orcid":false,"given":"Jan","family":"Derks","sequence":"additional","affiliation":[{"name":"Department of Periodontology Institute of Odontology The Sahlgrenska Academy at University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingemar","family":"Abrahamsson","sequence":"additional","affiliation":[{"name":"Department of Periodontology Institute of Odontology The Sahlgrenska Academy at University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan L.","family":"Wennstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Periodontology Institute of Odontology The Sahlgrenska Academy at University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Petzold","sequence":"additional","affiliation":[{"name":"Health Metrics The Sahlgrenska Academy at University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5864-6398","authenticated-orcid":false,"given":"Tord","family":"Berglundh","sequence":"additional","affiliation":[{"name":"Department of Periodontology Institute of Odontology The Sahlgrenska Academy at University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01631.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12332"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034514551754"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034515601961"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034515608832"},{"issue":"1","key":"e_1_2_7_7_1","first-page":"11","article-title":"Successful management of peri\u2010implantitis with a regenerative approach: A consecutive series of 51 treated implants with 3\u2010 to 7.5\u2010year follow\u2010up","volume":"32","author":"Froum S. 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