{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:50:45Z","timestamp":1790362245677,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,11,21]],"date-time":"2017-11-21T00:00:00Z","timestamp":1511222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"European Research Group on Periodontology"},{"name":"Geistlich Pharma AG"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2018,1]]},"abstract":"Abstract<\/jats:title>\n \n Aim<\/jats:title>\n \n To evaluate the non\u2010inferiority of the adjunct of a xenogeneic collagen matrix (\n CMX<\/jats:styled-content>\n ) or connective tissue graft (\n CTG<\/jats:styled-content>\n ) to coronally advanced flaps (\n CAF<\/jats:styled-content>\n ) for coverage of multiple adjacent recessions and compare superiority in patient\u2010reported outcomes (\n PROM<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Material and methods<\/jats:title>\n \n One hundred and eighty\u2010seven subjects (92\n CMX<\/jats:styled-content>\n ) with 485 recessions in 14 centres were randomized and followed up for 6\u00a0months. Patients filled daily diaries for 15\u00a0days to monitor patient\u2010reported experience. The primary outcome was changed in position of the gingival margin. Multilevel analysis used centre, subject and tooth as levels and baseline parameters as covariates.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Average baseline recession was 2.5\u00a0\u00b1\u00a01.0\u00a0mm. The surgery was 15.7\u00a0min shorter (95%\n CI<\/jats:styled-content>\n from 11.9 to 19.6,\n p<\/jats:italic>\n \u00a0<\u00a0.0001) and perceived lighter (11.9\n VAS<\/jats:styled-content>\n units, 95%\n CI<\/jats:styled-content>\n from 4.6 to 19.1,\n p<\/jats:italic>\n \u00a0=\u00a0.0014) in\n CMX<\/jats:styled-content>\n subjects. Time to recovery was 1.8\u00a0days shorter in\n CMX<\/jats:styled-content>\n . Six\u2010month root coverage was 1.7\u00a0\u00b1\u00a01.1\u00a0mm for\n CMX<\/jats:styled-content>\n and 2.1\u00a0\u00b1\u00a01.0\u00a0mm for\n CTG<\/jats:styled-content>\n (difference of 0.44\u00a0mm, 95%\n CI<\/jats:styled-content>\n from 0.25 to 0.63\u00a0mm). The upper limit of the confidence interval was over the non\u2010inferiority margin of 0.25\u00a0mm. Odds of complete root coverage were significantly higher for\n CTG<\/jats:styled-content>\n (\n OR<\/jats:styled-content>\n \u00a0=\u00a04.0, 95%\n CI<\/jats:styled-content>\n 1.8\u20138.8).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Replacing\n CTG<\/jats:styled-content>\n with\n CMX<\/jats:styled-content>\n shortens time to recovery and decreases morbidity, but the tested generation of devices is probably inferior to autologous\n CTG<\/jats:styled-content>\n in terms of root coverage. Significant variability in\n PROM<\/jats:styled-content>\n s was observed among centres.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jcpe.12834","type":"journal-article","created":{"date-parts":[[2017,10,31]],"date-time":"2017-10-31T07:16:36Z","timestamp":1509434196000},"page":"78-88","source":"Crossref","is-referenced-by-count":159,"title":["Xenogenic collagen matrix or autologous connective tissue graft as adjunct to coronally advanced flaps for coverage of multiple adjacent gingival recession: Randomized trial assessing non\u2010inferiority in root coverage and superiority in oral health\u2010related quality of life"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2743-0137","authenticated-orcid":false,"given":"Maurizio S.","family":"Tonetti","sequence":"first","affiliation":[{"name":"European Research Group on Periodontology Genova Italy"},{"name":"Department of Periodontology Hong Kong University Hong Kong Hong 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