{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T10:21:00Z","timestamp":1774520460165,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,12,27]],"date-time":"2017-12-27T00:00:00Z","timestamp":1514332800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI16\/00301"],"award-info":[{"award-number":["PI16\/00301"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>We aimed to evaluate serum <jats:styled-content style=\"fixed-case\">RBP<\/jats:styled-content>4 levels before and after periodontal therapy in lean and obese subjects with chronic periodontitis (<jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>) in order to determine its possible association with periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This is an interventional study for which a total of 112 lean and 119 obese subjects were recruited. Patients with <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> were evaluated before and after three months of non\u2010surgical periodontal treatment. Periodontal, anthropometric, biochemical parameters and serum levels of <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106, hs\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">RBP<\/jats:styled-content>4 were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum <jats:styled-content style=\"fixed-case\">RBP<\/jats:styled-content>4 levels were associated with an increased probability of periodontitis (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a01.60; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.02\u20102.50), showing patients with <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> to have higher <jats:styled-content style=\"fixed-case\">RBP<\/jats:styled-content>4 levels than those without <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> in both lean and obese populations (3.35 vs 3.06 and 3.74 vs 3.21, respectively). Following periodontal treatment, <jats:styled-content style=\"fixed-case\">RBP<\/jats:styled-content>4 and <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 decreased, and all periodontal parameters improved to the same extent in both groups, except for number of teeth with probing depth (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>) \u22654\u00a0mm, which improved to a less extent in obese than in lean subjects. In the multivariable regression model, the number of teeth with <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> \u22654\u00a0mm was independently associated with <jats:styled-content style=\"fixed-case\">RBP<\/jats:styled-content>4 (\u03b2\u00a0=\u00a00.192).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">RBP<\/jats:styled-content>4 was associated with chronic periodontitis before and after non\u2010surgical periodontal treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12840","type":"journal-article","created":{"date-parts":[[2017,11,18]],"date-time":"2017-11-18T13:52:41Z","timestamp":1511013161000},"page":"336-344","source":"Crossref","is-referenced-by-count":19,"title":["Levels of serum retinol\u2010binding protein 4 before and after non\u2010surgical periodontal treatment in lean and obese subjects: An interventional 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