{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:11:24Z","timestamp":1787015484151,"version":"build-2736575974"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,3,9]],"date-time":"2018-03-09T00:00:00Z","timestamp":1520553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01ZZ96030"],"award-info":[{"award-number":["01ZZ96030"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01ZZ0701"],"award-info":[{"award-number":["01ZZ0701"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"Abstract<\/jats:title>\n \n Aim<\/jats:title>\n To investigate the relation between oral health status and microcirculation, we analysed the association between periodontitis and number of teeth with retinal vessel diameters in a population\u2010based study.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We analysed data from the Study of Health in Pomerania\u2010TREND (\n SHIP<\/jats:styled-content>\n \u2010\n TREND<\/jats:styled-content>\n ). All subjects (3,183 for number of teeth, 3,013 for mean probing depth and 2,894 for mean attachment level) underwent nonmydriatic funduscopy and dental examination. We measured central retinal arteriolar (\n CRAE<\/jats:styled-content>\n ), venular (\n CRVE<\/jats:styled-content>\n ) vessel diameters and calculated arterio\u2010venous ratio (\n AVR<\/jats:styled-content>\n ) from static vessel analysis (SVA). Periodontal status was assessed using the case definition of the Center for Disease Control and Prevention\/American Academy of Periodontology (\n CDC<\/jats:styled-content>\n \/\n AAP<\/jats:styled-content>\n ). Data were analysed by linear (CRAE, CRVE, AVR) and logistic regression (\n AVR<\/jats:styled-content>\n \u00a0<\u00a00.8) adjusted for age, sex, smoking status, alcohol consumption, body mass index, systolic blood pressure, hs\n CRP<\/jats:styled-content>\n and type\u20102\u2010diabetes mellitus.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Only in men, significant associations were found between periodontal and retinal conditions\n .<\/jats:bold>\n Severe periodontitis [\u03b2\u00a0=\u00a0\u22120.0120 (\u22120.0218; \u22120.0007 95%\u2010\n CI<\/jats:styled-content>\n )] and mean probing depth [\u03b2\u00a0=\u00a0\u22120.0054 (\u22120.0105; \u22120.0002 95%\u2010\n CI<\/jats:styled-content>\n )] were inversely associated with\n AVR<\/jats:styled-content>\n ; severe periodontitis [\u03b2\u00a0=\u00a03.80 (0.61; 6.98 95%\u2010\n CI<\/jats:styled-content>\n )], mean probing depth [\u03b2\u00a0=\u00a01.86 (0.23; 3.49 95%\u2010\n CI<\/jats:styled-content>\n )] and mean attachment level [\u03b2\u00a0=\u00a01.31 (0.34; 2.27 95%\u2010\n CI<\/jats:styled-content>\n )] with\n CRVE<\/jats:styled-content>\n and mean attachment level with\n CRAE<\/jats:styled-content>\n [\u03b2\u00a0=\u00a00.91 (0.14; 1.69 95%\u2010\n CI<\/jats:styled-content>\n )].\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Our results point towards an association between periodontal conditions and\n AVR<\/jats:styled-content>\n in men. Periodontitis may impact microvascular endothelium function. Improving oral health to reduce periodontitis might lead to reduced risk for other age\u2010related diseases.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jcpe.12872","type":"journal-article","created":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T18:46:37Z","timestamp":1517424397000},"page":"404-412","source":"Crossref","is-referenced-by-count":9,"title":["Cross\u2010sectional association between oral health and retinal microcirculation"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1817-6755","authenticated-orcid":false,"given":"Stefanie","family":"Samietz","sequence":"first","affiliation":[{"name":"Department of Prosthodontics, Gerostomatology and Biomaterials Center for Oral Health University Medicine Greifswald Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemens","family":"J\u00fcrgens","sequence":"additional","affiliation":[{"name":"Institute for Community Medicine University Medicine Greifswald Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Till","family":"Ittermann","sequence":"additional","affiliation":[{"name":"Institute for Community Medicine University Medicine Greifswald Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birte","family":"Holtfreter","sequence":"additional","affiliation":[{"name":"Unit of Periodontology Department of Restorative Dentistry, Periodontology, Endodontology, Preventive Dentistry and Pedodontics Center for Oral Health University Medicine Greifswald Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5950-2716","authenticated-orcid":false,"given":"Christiane","family":"Pink","sequence":"additional","affiliation":[{"name":"Unit of Periodontology Department of Restorative Dentistry, Periodontology, Endodontology, Preventive Dentistry and Pedodontics Center for Oral Health University Medicine Greifswald Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Schipf","sequence":"additional","affiliation":[{"name":"Institute for Community Medicine University Medicine Greifswald Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reiner","family":"Biffar","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Gerostomatology and Biomaterials Center for Oral Health University Medicine Greifswald Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"V\u00f6lzke","sequence":"additional","affiliation":[{"name":"Institute for Community Medicine University Medicine Greifswald Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Kocher","sequence":"additional","affiliation":[{"name":"Unit of Periodontology Department of Restorative Dentistry, Periodontology, Endodontology, Preventive Dentistry and Pedodontics 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