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Quantitative polymerase chain reaction assays were designed to identify the serotypes from saliva samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>Aggregatibacter actinomycetemcomitans<\/jats:italic> serotype frequencies were as follows: serotype \u201cc\u201d 35.7%, \u201cb\u201d 28.6%, \u201ca\u201d 26.2%, \u201ce\u201d 7.1%, \u201cd\u201d 2.4% and \u201cf\u201d 0%. The subjects with a detectable serotype had less teeth and higher bleeding on probing than those with no serotype. Serotypes \u201cb\u201d and \u201cc\u201d associated with periodontal probing depths and periodontal inflammatory burden. The saliva and subgingival bacterium quantities and serum antibody levels against <jats:italic>A.\u00a0actinomycetemcomitans<\/jats:italic> were highest in patients harbouring serotype \u201cc.\u201d Serotypes \u201cb\u201d and \u201cc\u201d were most frequent (59.3%) in patients with <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.040), and they associated with the risk of stable <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> with an odds ratio of 2.67 (95% confidence interval 1.06\u20137.44). Also, the severity of <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.018) associated with serotypes \u201cb\u201d and \u201cc.\u201d<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:italic>Aggregatibacter actinomycetemcomitans<\/jats:italic> serotypes \u201cb\u201d and \u201cc\u201d associate with both periodontal and <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> status. Detectable serotypes associate with the quantity and the serology of the bacterium emphasizing both local and systemic effect of the <jats:italic>A.\u00a0actinomycetemcomitans<\/jats:italic> serotypes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12873","type":"journal-article","created":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T23:52:42Z","timestamp":1517442762000},"page":"413-421","source":"Crossref","is-referenced-by-count":26,"title":["<i>Aggregatibacter actinomycetemcomitans<\/i> serotypes associate with periodontal and coronary artery disease status"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4875-0682","authenticated-orcid":false,"given":"Milla","family":"Pieti\u00e4inen","sequence":"first","affiliation":[{"name":"Oral and Maxillofacial Diseases University of Helsinki and Helsinki University Hospital  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. A. Elisa","family":"Kopra","sequence":"additional","affiliation":[{"name":"Oral and Maxillofacial Diseases University of Helsinki and Helsinki University Hospital  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juha","family":"Vuorenkoski","sequence":"additional","affiliation":[{"name":"Oral and Maxillofacial Diseases University of Helsinki and Helsinki University Hospital  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7576-090X","authenticated-orcid":false,"given":"Aino","family":"Salminen","sequence":"additional","affiliation":[{"name":"Oral and Maxillofacial Diseases University of Helsinki and Helsinki University Hospital  Helsinki Finland"},{"name":"Department of Dental Medicine Huddinge Division of Periodontology Karolinska Institutet  Huddinge 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