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While experimental models and humans diagnosed with periodontitis demonstrate an antigenic specificity for particular oral bacteria, we have a limited understanding of (i) how ageing affects the adaptive immune responses to these bacteria that chronically colonize the oral cavity for decades prior to disease expression and (ii) how the magnitude and specificity of the response interface with pathogens that emerge within the bacterial ecology during exacerbations of disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Serum antibody levels to a group of pathogenic and commensal oral bacteria were measured in a population of individuals from 21 to 74\u00a0years of age, stratified based on clinical status of the periodontium, smoking and sex.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Clinical parameters were not significantly different within health, gingivitis or periodontitis groups related to age. Antibody to oral pathogens and commensals was similar in different age groups in each of the clinical categories, with no age correlation noted in the periodontitis patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The adaptive immune responses to oral bacteria that chronically colonize the oral cavity appear generally unaffected by age, but clearly are linked to the extent of disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12881","type":"journal-article","created":{"date-parts":[[2018,2,24]],"date-time":"2018-02-24T13:36:37Z","timestamp":1519479397000},"page":"680-692","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Ageing effects on humoral immune responses in chronic periodontitis"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9743-6585","authenticated-orcid":false,"given":"Jeffrey L.","family":"Ebersole","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences School of Dental Medicine University of Nevada Las Vegas  Las Vegas NV USA"},{"name":"Center for Oral Health Research College of Dentistry University of Kentucky  Lexington KY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohanad","family":"Al\u2010Sabbagh","sequence":"additional","affiliation":[{"name":"Division of Periodontology College of Dentistry University of Kentucky  Lexington KY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Octavio A.","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Center for Oral Health Research College of Dentistry University of Kentucky  Lexington KY USA"},{"name":"Division of Periodontology College of Dentistry University of Kentucky  Lexington KY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Dolph R.","family":"Dawson","sequence":"additional","affiliation":[{"name":"Center for Oral Health Research College of Dentistry University of Kentucky  Lexington KY USA"},{"name":"Division of Periodontology College of Dentistry University of Kentucky  Lexington KY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060431"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00788.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2012.00449.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2005.03.017"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2013.852531"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034510387794"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/503754"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00856.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.080474"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2003.03109.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12005"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12135"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00272"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.080464"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1993.tb02121.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2008.01051.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12146"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.1987.tb00290.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2015.140520"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034512457373"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2016.160013"},{"key":"e_1_2_7_23_1","first-page":"515","article-title":"Risk indicators for periodontitis in US Adults: National Health and Nutrition Examination Survey (NHANES) 2009\u20132012","volume":"95","author":"Eke P. 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