{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T18:25:14Z","timestamp":1788200714249,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T00:00:00Z","timestamp":1523836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Osteonecrosis of the jaw associated with bisphosphonates is currently called medication\u2010related osteonecrosis of the jaw (<jats:styled-content style=\"fixed-case\">MRONJ<\/jats:styled-content>), given that in addition to bisphosphonates, jaw osteonecrosis has been related to the administration of other antiresorptive and antiangiogenic drugs, such as denosumab, sunitinib, bevacizumab and ipilimumab.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Presentation<\/jats:title><jats:p>A 77\u2010year\u2010old patient with osteoporosis treated with subcutaneous injections of denosumab at an interval of 6\u00a0months is presented. The patient developed <jats:styled-content style=\"fixed-case\">MRONJ<\/jats:styled-content> after receiving a non\u2010surgical periodontal therapy. Although the <jats:styled-content style=\"fixed-case\">MRONJ<\/jats:styled-content> was initially classified as a stage I lesion in this patient, cone beam computed tomography images confirmed the presence of a significant osteolytic lesion. Treatment consisted of the administration of chlorhexidine mouthwash and systemic doxycycline, exodontia of the involved teeth, sequestrectomy and complete surgical debridement of the necrotic bone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>To our knowledge, this is the first case reported in the literature of <jats:styled-content style=\"fixed-case\">MRONJ<\/jats:styled-content> following non\u2010surgical periodontal therapy in a patient with osteoporosis treated with denosumab. The risk of <jats:styled-content style=\"fixed-case\">MRONJ<\/jats:styled-content> development after a periodontal procedure and how to prevent this complication are still unknown.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12882","type":"journal-article","created":{"date-parts":[[2018,2,26]],"date-time":"2018-02-26T08:20:40Z","timestamp":1519633240000},"page":"570-577","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Denosumab\u2010related osteonecrosis of the jaw following non\u2010surgical periodontal therapy: A case report"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5349-1091","authenticated-orcid":false,"given":"M\u00e1rcio","family":"Diniz\u2010Freitas","sequence":"first","affiliation":[{"name":"Medical\u2010Surgical Dentistry Research Group (OMEQUI) Health Research Institute of Santiago de Compostela (IDIS) University of Santiago de Compostela (USC)  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Fern\u00e1ndez\u2010Feijoo","sequence":"additional","affiliation":[{"name":"Medical\u2010Surgical Dentistry Research Group (OMEQUI) Health Research Institute of Santiago de Compostela (IDIS) University of Santiago de Compostela (USC)  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Diz Dios","sequence":"additional","affiliation":[{"name":"Medical\u2010Surgical Dentistry Research Group (OMEQUI) Health Research Institute of Santiago de Compostela (IDIS) University of Santiago de Compostela (USC)  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiana","family":"Pousa","sequence":"additional","affiliation":[{"name":"Periodontology Unit School of Medicine and Dentistry University of Santiago de Compostela (USC)  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacobo","family":"Limeres","sequence":"additional","affiliation":[{"name":"Medical\u2010Surgical Dentistry Research Group (OMEQUI) Health Research Institute of Santiago de Compostela (IDIS) University of Santiago de Compostela (USC)  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2017.05.028"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12447"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2014.04.009"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2013.12.007"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2009.01.006"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.2010.516249"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.20963"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adaj.2017.04.002"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2012.01.046"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.10682.1"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12632"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12455"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2016.11.011"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-017-4063-7"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3191"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.31.3304"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2405"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2015.09.011"},{"key":"e_1_2_6_20_1","article-title":"Risk factors for medication\u2010related osteonecrosis of the jaws: A systematic review","author":"McGowan K.","year":"2017","journal-title":"Oral Diseases"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(03)00720-1"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/adj.12217"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2009-0115"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1479"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2012.10.014"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2016.03.008"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2014.11.014"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.2014.811"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2014.04.031"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-007-0540-8"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reuma.2012.06.007"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon.15.232"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-010-1061-0"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2012.06.020"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2017.09.014"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2017.6121"}],"container-title":["Journal of Clinical Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcpe.12882","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpe.12882","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T12:23:59Z","timestamp":1695471839000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcpe.12882"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,16]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1111\/jcpe.12882"],"URL":"https:\/\/doi.org\/10.1111\/jcpe.12882","archive":["Portico"],"relation":{},"ISSN":["0303-6979","1600-051X"],"issn-type":[{"value":"0303-6979","type":"print"},{"value":"1600-051X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,16]]},"assertion":[{"value":"2018-02-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}