{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T10:21:36Z","timestamp":1763202096657,"version":"3.37.3"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T00:00:00Z","timestamp":1523836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2012\/00680\u20109"],"award-info":[{"award-number":["2012\/00680\u20109"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2018,5]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>The effects of green tea on the modulation of vascularization during the progression of spontaneous periodontitis in long\u2010term hyperglycaemia in streptozotocin\u2010induced type 1 diabetic (T1D) rats were evaluated.<\/jats:p><\/jats:sec>Materials and Methods<\/jats:title>Wistar<\/jats:italic> rats normoglycaemic (NG<\/jats:styled-content>) and T1D were divided into two control groups, which received water (NG<\/jats:styled-content>\u2010W and T1D\u2010W) and two experimental groups that received green tea (NG<\/jats:styled-content>\u2010GT<\/jats:styled-content> and T1D\u2010GT<\/jats:styled-content>). Periodontal structures were evaluated by microtomographic and histological analyses. Number of immunostained cells for VEGF<\/jats:styled-content> (NcVEGF<\/jats:styled-content>+\/mm2<\/jats:sup>) and CD<\/jats:styled-content>31 (NcCD<\/jats:styled-content>31+\/mm2<\/jats:sup>), as well microvessel density (MVD<\/jats:styled-content>) in the periodontal ligament (PDL<\/jats:styled-content>) were evaluated.<\/jats:p><\/jats:sec>Results<\/jats:title>Long\u2010term hyperglycaemia in T1D\u2010W rats induced vascular alterations in PDL<\/jats:styled-content> with a reduction of 36% in MVD<\/jats:styled-content>, a decrease of 33% in NcCD<\/jats:styled-content>31+\/mm2<\/jats:sup> and an increase of 53% in NcVEGF<\/jats:styled-content>+\/mm2<\/jats:sup>. Concomitantly, a severe degree of periodontitis with higher reduction in bone volume and periodontal bone level was observed. In T1D\u2010GT<\/jats:styled-content>, green tea maintained the MVD<\/jats:styled-content>, NcCD<\/jats:styled-content>31+\/mm2<\/jats:sup> and NcVEGF<\/jats:styled-content>+\/mm2<\/jats:sup> in the PDL<\/jats:styled-content> similar to normoglycaemic groups. Clinically, in T1D\u2010GT<\/jats:styled-content> rats, green tea reduced dental plaque accumulation and the degree of periodontitis when compared to T1D\u2010W.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Daily green tea consumption has a therapeutic effect on the diabetic vascular disorder in PDL<\/jats:styled-content> and the progression of periodontitis in long\u2010term hyperglycaemia in T1D rats.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12883","type":"journal-article","created":{"date-parts":[[2018,3,3]],"date-time":"2018-03-03T08:56:41Z","timestamp":1520067401000},"page":"557-569","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Green tea prevents vascular disturbs and attenuates periodontal breakdown in long\u2010term hyperglycaemia in T1D rats"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9902-5464","authenticated-orcid":false,"given":"Daniela Pereira","family":"Catanzaro","sequence":"first","affiliation":[{"name":"Department of Biological Sciences Bauru School of Dentistry University of S\u00e3o Paulo Bauru S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5494-6569","authenticated-orcid":false,"given":"Ever Elias","family":"Mena Laura","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Bauru School of Dentistry University of S\u00e3o Paulo Bauru S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1287-5974","authenticated-orcid":false,"given":"Tania Mary","family":"Cestari","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Bauru School of Dentistry University of S\u00e3o Paulo Bauru S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0145-7718","authenticated-orcid":false,"given":"Ricardo Vinicius Nunes","family":"Arantes","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Bauru School of Dentistry University of S\u00e3o Paulo Bauru S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5071-8382","authenticated-orcid":false,"given":"Gustavo Pompermaier","family":"Garlet","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Bauru School of Dentistry University of S\u00e3o Paulo Bauru S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5593-0999","authenticated-orcid":false,"given":"Rumio","family":"Taga","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Bauru School of Dentistry University of S\u00e3o Paulo Bauru S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8225-3164","authenticated-orcid":false,"given":"Gerson Francisco","family":"Assis","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Bauru School of Dentistry University of S\u00e3o Paulo Bauru S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,4,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.090239"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2016.03.016"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.6.1615"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.120076"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-5491.2000.00350.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12071"},{"issue":"4","key":"e_1_2_9_8_1","first-page":"293","article-title":"Green tea intake as an adjunct to mechanical periodontal therapy for the management of mild to moderate chronic periodontitis: A randomized controlled clinical trial","volume":"14","author":"Chopra A.","year":"2016","journal-title":"Oral Health & Preventive Dentistry"},{"issue":"13","key":"e_1_2_9_9_1","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1242\/jcs.111.13.1853","article-title":"Vascular endothelial growth factor induces VE\u2010cadherin tyrosine phosphorylation in endothelial cells","volume":"111","author":"Esser S.","year":"1998","journal-title":"Journal of Cell Science"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0134784"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.3.391"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/2045-824X-5-9"},{"issue":"1","key":"e_1_2_9_13_1","first-page":"109","article-title":"Green tea (Camellia sinensis) supplementation to diabetic rats improves serum and hepatic oxidative stress markers","volume":"12","author":"Haidari F.","year":"2013","journal-title":"Iranian Journal of Pharmaceutical Research"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13167-010-0016-3"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2532"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0084603"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.23416"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI82585"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612811319340008"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0124909"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2040-1124.2010.00018.x"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.080510"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.29.02.06.dc05-1355"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2011.106"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00736.x"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12142"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01338.x"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.050459"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07201"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01305-15"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.07705.x"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2008.49.3.357"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2014.02.016"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0022480"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871526515666150831144528"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2009.01500.x"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-1185"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2006.01.001"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1997.68.12.1237"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.5483\/BMBRep.2008.41.4.278"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2016.160279"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1590\/0103-6440201600533"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12147"}],"container-title":["Journal of Clinical Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcpe.12883","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpe.12883","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T12:23:29Z","timestamp":1695471809000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcpe.12883"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,16]]},"references-count":42,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1111\/jcpe.12883"],"URL":"https:\/\/doi.org\/10.1111\/jcpe.12883","archive":["Portico"],"relation":{},"ISSN":["0303-6979","1600-051X"],"issn-type":[{"type":"print","value":"0303-6979"},{"type":"electronic","value":"1600-051X"}],"subject":[],"published":{"date-parts":[[2018,4,16]]},"assertion":[{"value":"2018-02-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}