{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T20:48:38Z","timestamp":1771274918468,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,6,19]],"date-time":"2018-06-19T00:00:00Z","timestamp":1529366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012127","name":"Augusta University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012127","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2018,8]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Recombinant human bone morphogenetic protein\u20102 in an absorbable collagen sponge carrier (rhBMP<\/jats:styled-content>\u20102\/ACS<\/jats:styled-content>) has been shown to support significant bone formation when used to augment the maxillary sinus for implant dentistry. Nevertheless, bone biomaterials have been suggested to extend rhBMP<\/jats:styled-content>\u20102\/ACS<\/jats:styled-content> with limited support of the merits of such approaches.<\/jats:p><\/jats:sec>Objectives<\/jats:title>To evaluate local bone formation\/dental implant osseointegration following implantation of rhBMP<\/jats:styled-content>\u20102\/ACS<\/jats:styled-content> combined with a ceramic bone biomaterial using a mini\u2010pig sinus augmentation model.<\/jats:p><\/jats:sec>Methods<\/jats:title>Twelve adult G\u00f6ttingen mini\u2010pigs received rhBMP<\/jats:styled-content>\u20102\/ACS<\/jats:styled-content> (rhBMP<\/jats:styled-content>\u20102 adjusted to 0.43\u00a0mg\/cc) alone or combined with an off\u2010the\u2010shelf biphasic ceramic (15%\/85% HA<\/jats:styled-content>\/\u00df\u2010TCP<\/jats:styled-content>) biomaterial at 3:1, 1:1 and 1:3 ratios randomized to contra\u2010lateral maxillary sinus sites yielding rhBMP<\/jats:styled-content>\u20102\/ACS<\/jats:styled-content> fractions of 100%, 75%, 50% and 25%, respectively. A 4\u2010cc implant volume was used for all sites. Two threaded dental implants (\u00f84.0\u00a0\u00d7\u00a011.5\u00a0mm) were placed at each site. The animals were euthanized at 8\u00a0weeks for histologic analysis.<\/jats:p><\/jats:sec>Results<\/jats:title>Surgical execution and healing were generally uneventful, infraorbital local swelling was observed in all animals until suture removal. rhBMP<\/jats:styled-content>\u20102\/ACS<\/jats:styled-content> combined with the ceramic biomaterial did not significantly enhance local bone formation (range 9.0\u00a0\u00b1\u00a01.5 to 9.7\u00a0\u00b1\u00a02.1\u00a0mm) compared with rhBMP<\/jats:styled-content>\u20102\/ACS<\/jats:styled-content> alone (8.6\u00a0\u00b1\u00a01.1\u00a0mm; p\u00a0<\/jats:italic>>\u00a0<\/jats:italic>0.05). Variations in rhBMP<\/jats:styled-content>\u20102\/ACS<\/jats:styled-content> to ceramic matrix ratios yielding rhBMP<\/jats:styled-content>\u20102 doses approximating 0.4, 0.9, 1.3 and 1.7\u00a0mg\/sinus did not appreciably influence bone formation\/osseointegration.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Whereas rhBMP<\/jats:styled-content>\u20102\/ACS<\/jats:styled-content> supports significant bone formation\/osseointegration in the mini\u2010pig sinus augmentation model and thus appears an effective alternative for sinus augmentation procedures, adding a ceramic biomaterial to rhBMP<\/jats:styled-content>\u20102\/ACS<\/jats:styled-content> does not produce meaningful biological advantages.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12921","type":"journal-article","created":{"date-parts":[[2018,5,14]],"date-time":"2018-05-14T12:56:13Z","timestamp":1526302573000},"page":"1005-1013","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Sinus augmentation using rhBMP<\/scp>\u20102\/ACS<\/scp> in a mini\u2010pig model: Influence of an adjunctive ceramic bone biomaterial"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4092-908X","authenticated-orcid":false,"given":"Cristiano","family":"Susin","sequence":"first","affiliation":[{"name":"Laboratory for Applied Periodontal & Craniofacial Research (LAPCR) Dental College of Georgia Augusta University Augusta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaebum","family":"Lee","sequence":"additional","affiliation":[{"name":"Laboratory for Applied Periodontal & Craniofacial Research (LAPCR) Dental College of Georgia Augusta University Augusta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5452-3822","authenticated-orcid":false,"given":"Tiago","family":"Fiorini","sequence":"additional","affiliation":[{"name":"Laboratory for Applied Periodontal & Craniofacial Research (LAPCR) Dental College of Georgia Augusta University Augusta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rubens Moreno","family":"de Freitas","sequence":"additional","affiliation":[{"name":"Laboratory for Applied Periodontal & Craniofacial Research (LAPCR) Dental College of Georgia Augusta University Augusta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsien\u2010Chung","family":"Chiu","sequence":"additional","affiliation":[{"name":"Laboratory for Applied Periodontal & Craniofacial Research (LAPCR) Dental College of Georgia Augusta University Augusta 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