{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:29:06Z","timestamp":1790195346532,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,10,21]],"date-time":"2018-10-21T00:00:00Z","timestamp":1540080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"S\u00e3o Paulo State Research Foundation","award":["#07\/55291-9"],"award-info":[{"award-number":["#07\/55291-9"]}]},{"name":"S\u00e3o Paulo State Research Foundation","award":["#11\/14872-4"],"award-info":[{"award-number":["#11\/14872-4"]}]},{"name":"S\u00e3o Paulo State Research Foundation","award":["#13\/01072-5"],"award-info":[{"award-number":["#13\/01072-5"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate if non\u2010diabetic subjects with periodontitis respond better than subjects with type 2 diabetes to the treatment protocol of scaling and root planing (<jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>), metronidazole (<jats:styled-content style=\"fixed-case\">MTZ<\/jats:styled-content>) and amoxicillin (<jats:styled-content style=\"fixed-case\">AMX<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Diabetic and nondiabetic subjects with severe periodontitis received <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">MTZ<\/jats:styled-content> (400\u00a0mg\/thrice a day [<jats:styled-content style=\"fixed-case\">TID<\/jats:styled-content>])\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">AMX<\/jats:styled-content> (500\u00a0mg\/<jats:styled-content style=\"fixed-case\">TID<\/jats:styled-content>) for 14\u00a0days. Subgingival biofilm samples were analyzed by checkerboard <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>\u2013<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> hybridization for 40 bacterial species. Subjects were monitored at baseline, 3, 6 and 12\u00a0months post\u2010therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010nine type 2 diabetics and 29 non\u2010diabetic subjects participated of this study. Of the non\u2010diabetics and diabetics, 68.9% and 75.9%, respectively, reached the clinical endpoint for treatment (\u22644 sites with probing depth [PD] \u22655\u00a0mm) at 1\u00a0year post\u2010therapy (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.05). The diabetic group presented lower mean clinical attachment gain from baseline to 1\u00a0year post\u2010therapy and higher mean proportions of the red and orange complexes than the non\u2010diabetic group (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Non\u2010diabetic subjects with severe periodontitis did not respond better than type 2 diabetic subjects to the treatment protocol of <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">MTZ<\/jats:styled-content>\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">AMX<\/jats:styled-content>, both in terms of achieving the clinical endpoint for treatment and of <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> improvement. Diabetic subjects exhibited a slightly worse microbiological response and showed a healing process more associated with gingival recession than the non\u2010diabetics.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12994","type":"journal-article","created":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T06:36:20Z","timestamp":1533623780000},"page":"1326-1335","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Clinical and microbiological effects of scaling and root planing, metronidazole and amoxicillin in the treatment of diabetic and non\u2010diabetic subjects with periodontitis: A cohort study"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8872-5943","authenticated-orcid":false,"given":"Poliana Mendes","family":"Duarte","sequence":"first","affiliation":[{"name":"Department of Periodontology Dental Research Division Guarulhos University  Guarulhos S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2293-3392","authenticated-orcid":false,"given":"Magda","family":"Feres","sequence":"additional","affiliation":[{"name":"Department of Periodontology Dental Research Division Guarulhos University  Guarulhos S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina Lameh Smeili","family":"Yassine","sequence":"additional","affiliation":[{"name":"Department of Periodontology Dental Research Division Guarulhos University  Guarulhos S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geisla Mary Silva","family":"Soares","sequence":"additional","affiliation":[{"name":"Department of Stomatology Federal University of Paran\u00e1  Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamires Szeremeske","family":"Miranda","sequence":"additional","affiliation":[{"name":"Department of Periodontology Dental Research Division Guarulhos University  Guarulhos S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Faveri","sequence":"additional","affiliation":[{"name":"Department of Periodontology Dental Research Division Guarulhos University  Guarulhos S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belen","family":"Retamal\u2010Valdes","sequence":"additional","affiliation":[{"name":"Department of Periodontology Dental Research Division Guarulhos University  Guarulhos S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciene Cristina","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Department of Periodontology Dental Research Division Guarulhos University  Guarulhos S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,21]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"1203","article-title":"Evaluation of adjunctive systemic doxycycline with non\u2010surgical periodontal therapy within type 2 diabetic patients","volume":"35","author":"Al\u2010Nowaiser A. 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