{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T14:43:05Z","timestamp":1792248185603,"version":"4.4.0"},"reference-count":47,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T00:00:00Z","timestamp":1537747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["#480982\/2013\u20109"],"award-info":[{"award-number":["#480982\/2013\u20109"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      This randomized placebo\u2010controlled clinical trial evaluated the effect of\n                      <jats:italic>Bifidobacterium animalis<\/jats:italic>\n                      subsp\n                      <jats:italic>. lactis<\/jats:italic>\n                      (\n                      <jats:italic>B.\u00a0lactis<\/jats:italic>\n                      ) HN019\u2010containing probiotic lozenges as adjuvant to scaling and root planing (SRP) in patients with generalized chronic periodontitis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Forty\u2010one chronic periodontitis patients were recruited and monitored clinically, immunologically, and microbiologically at baseline (before SRP) and 30 and 90\u00a0days after SRP. All patients were randomly assigned to a Test (SRP\u00a0+\u00a0Probiotic,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a020) or Control (SRP\u00a0+\u00a0Placebo,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a021) group. The probiotic lozenges were used twice a day for 30\u00a0days. The data were statistically analysed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The Test group presented a decrease in probing pocket depth and a clinical attachment gain significantly higher than those of the Control group at 90\u00a0days. The Test group also demonstrated significantly fewer periodontal pathogens of red and orange complexes, as well as lower proinflammatory cytokine levels when compared to the Control group. Only the Test group showed an increase in the number of\n                      <jats:italic>B.\u00a0lactis<\/jats:italic>\n                      HN019 DNA copies on subgingival biofilm at 30 and 90\u00a0days.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The use of\n                      <jats:italic>B.\u00a0lactis<\/jats:italic>\n                      HN019 as an adjunct to SRP promotes additional clinical, microbiological, and immunological benefits in the treatment of chronic periodontitis (NCT03408548).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.12995","type":"journal-article","created":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T02:37:14Z","timestamp":1533609434000},"page":"1198-1210","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":203,"title":["Effects of\n                    <i>Bifidobacterium<\/i>\n                    probiotic on the treatment of chronic periodontitis: A randomized clinical trial"],"prefix":"10.1111","volume":"45","author":[{"given":"Marcos M.","family":"Invernici","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery and Periodontology School of Dentistry of Ribeirao Preto University of Sao Paulo \u2013 USP  Ribeirao Preto SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9rgio L.","family":"Salvador","sequence":"additional","affiliation":[{"name":"Department of Clinical Analyses School of Pharmaceutical Sciences of Ribeirao Preto University of Sao Paulo \u2013 USP  Ribeirao Preto SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro H. 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