{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:11:38Z","timestamp":1787015498738,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T00:00:00Z","timestamp":1542672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003359","name":"Generalitat Valenciana","doi-asserted-by":"publisher","award":["ACIF\/2015\/226"],"award-info":[{"award-number":["ACIF\/2015\/226"]}],"id":[{"id":"10.13039\/501100003359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CPII16\/0037"],"award-info":[{"award-number":["CPII16\/0037"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["FI14\/00350"],"award-info":[{"award-number":["FI14\/00350"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI16\/00301"],"award-info":[{"award-number":["PI16\/00301"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI16\/01083"],"award-info":[{"award-number":["PI16\/01083"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the relationship between oxidative stress parameters in polymorphonuclear leucocytes (PMNs) and PMN\u2013endothelial cell interactions in patients with chronic periodontitis (CP) according to different degrees of severity of the disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      For this cross\u2010sectional study, 182 subjects were divided into four groups according to degree of CP: without CP (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a037), mild CP (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a059), moderate CP (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a051), and severe CP (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a035). We determined anthropometric and biochemical variables, periodontal parameters, inflammatory markers, oxidative stress parameters (superoxide and mitochondrial membrane potential), and PMN\u2013endothelium cell interactions (rolling flux, velocity, and adhesion).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Systemic inflammatory markers\u2014C\u2010reactive protein, leucocyte count, TNF\u03b1, and retinol\u2010binding protein 4\u2014were altered in the group with CP. Total superoxide was augmented in patients with moderate and severe periodontitis, whereas mitochondrial membrane potential did not change. Furthermore, PMNs adhesion and rolling flux were increased in subjects with CP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In a systemic proinflammatory environment, PMNs from patients with CP exhibit hyperactivity and produce higher amounts of superoxide. In parallel with this, an increase in PMNs rolling flux and cell adhesion to the endothelium suggests the presence of alterations of PMN\u2013endothelium interactions in patients with CP that can lead to atherosclerosis and cardiovascular complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.13027","type":"journal-article","created":{"date-parts":[[2018,10,26]],"date-time":"2018-10-26T00:03:32Z","timestamp":1540512212000},"page":"1429-1439","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Chronic periodontitis impairs polymorphonuclear leucocyte\u2013endothelium cell interactions and oxidative stress in humans"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1965-7099","authenticated-orcid":false,"given":"Mayte","family":"Martinez\u2010Herrera","sequence":"first","affiliation":[{"name":"Service of Stomatology University Hospital Doctor Peset\u2010FISABIO  Valencia Spain"},{"name":"Department of Stomatology University of Valencia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"L\u00f3pez\u2010Dom\u00e8nech","sequence":"additional","affiliation":[{"name":"Service of Endocrinology and Nutrition University Hospital Doctor Peset\u2010FISABIO  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Javier","family":"Silvestre","sequence":"additional","affiliation":[{"name":"Service of Stomatology University Hospital Doctor Peset\u2010FISABIO  Valencia Spain"},{"name":"Department of Stomatology University of Valencia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Silvestre\u2010Rangil","sequence":"additional","affiliation":[{"name":"Department of Stomatology University of Valencia  Valencia 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