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Human and herpesvirus mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> expression was quantified using quantitative <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>. Predicted targets of dysregulated mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s were identified using bioinformatics analysis, validated by dual luciferase assays and their expression assessed in healthy and diseased tissues.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our results show differential expression of mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s in both diseased groups compared to healthy counterparts. <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u201016 is identified as a novel target of mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s altered in disease. Expression analysis of genes predicted as target of differentially expressed mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s show significant changes in disease compared with healthy tissues. Finally, quantitation of four herpesvirus\u2010derived viral mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s show that the expression and prevalence of herpesvirus mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s in diseased gingiva of obese subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings show that mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> (both cellular and virus) expression is differentially responsive to local and systemic inflammation. Some of these mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s can modulate key cellular genes with direct consequences on inflammatory pathways suggesting their impact on oral tissue transcriptome and functions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13040","type":"journal-article","created":{"date-parts":[[2018,11,30]],"date-time":"2018-11-30T12:37:50Z","timestamp":1543581470000},"page":"51-61","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Dysregulation of human miRNAs and increased prevalence of <scp>HHV<\/scp> miRNAs in obese periodontitis subjects"],"prefix":"10.1111","volume":"46","author":[{"given":"Afsar R.","family":"Naqvi","sequence":"first","affiliation":[{"name":"Department of Periodontics University of Illinois at Chicago  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria F.","family":"Brambila","sequence":"additional","affiliation":[{"name":"Posgrado de Periodoncia Facultad de Odontologia Universidad Autonoma de Nuevo Le\u00f3n  Monterrey Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Posgrado de Periodoncia Facultad de Odontologia Universidad Autonoma de Nuevo Le\u00f3n  Monterrey Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Chapa","sequence":"additional","affiliation":[{"name":"Posgrado de Periodoncia Facultad de Odontologia Universidad Autonoma de Nuevo Le\u00f3n  Monterrey Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2194-1374","authenticated-orcid":false,"given":"Salvador","family":"Nares","sequence":"additional","affiliation":[{"name":"Department of Periodontics University of Illinois at Chicago  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.201500054"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2014.0581"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00263-16"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004410051293"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2337"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(98)00374-9"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep24980"},{"key":"e_1_2_8_9_1","first-page":"pii: 362","article-title":"miR\u201024 regulates macrophage polarization and plasticity","volume":"6","author":"Fordham J. 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