{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:04:53Z","timestamp":1791309893076,"version":"4.3.1"},"reference-count":88,"publisher":"Wiley","issue":"S21","license":[{"start":{"date-parts":[[2019,6,18]],"date-time":"2019-06-18T00:00:00Z","timestamp":1560816000000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2019,6]]},"abstract":"Abstract<\/jats:title>\n \n Aim<\/jats:title>\n \n The aim of this systematic review was to critically analyse the available evidence on the effect of different modalities of alveolar ridge preservation (\n ARP<\/jats:styled-content>\n ) as compared to tooth extraction alone in function of relevant clinical, radiographic and patient\u2010centred outcomes.\n <\/jats:p>\n <\/jats:sec>\n \n Material and Methods<\/jats:title>\n \n A comprehensive search aimed at identifying pertinent literature for the purpose of this review was conducted by two independent examiners. Only randomized clinical trials (\n RCT<\/jats:styled-content>\n s) that met the eligibility criteria were selected. Relevant data from these\n RCT<\/jats:styled-content>\n s were collated into evidence tables. Endpoints of interest included clinical, radiographic and patient\u2010reported outcome measures (\n PROM<\/jats:styled-content>\n s). Interventions reported in the selected studies were clustered into\n ARP<\/jats:styled-content>\n treatment modalities. All these different\n ARP<\/jats:styled-content>\n modalities were compared to the control therapy (i.e. spontaneous socket healing) in each individual study after a 3\u2010 to 6\u2010month healing period. Random\u2010effects meta\u2010analyses were conducted if at least two studies within the same\n ARP<\/jats:styled-content>\n treatment modality reported on the same outcome of interest.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A combined database, grey literature and hand search identified 3,003 records, of which 1,789 were screened after removal of duplicates. Following the application of the eligibility criteria, 25 articles for a total of 22\n RCT<\/jats:styled-content>\n s were included in the final selection, from which nine different\n ARP<\/jats:styled-content>\n treatment modalities were identified: (a) bovine bone particles (\n BBP<\/jats:styled-content>\n )\u00a0+\u00a0socket sealing (\n SS<\/jats:styled-content>\n ), (b) construct made of 90% bovine bone granules and 10% porcine collagen (\n BBG<\/jats:styled-content>\n \/\n PC<\/jats:styled-content>\n )\u00a0+\u00a0\n SS<\/jats:styled-content>\n , (c) cortico\u2010cancellous porcine bone particles (\n CPBP<\/jats:styled-content>\n )\u00a0+\u00a0\n SS<\/jats:styled-content>\n , (d) allograft particles (\n AG<\/jats:styled-content>\n )\u00a0+\u00a0\n SS<\/jats:styled-content>\n , (e) alloplastic material (\n AP<\/jats:styled-content>\n ) with or without\n SS<\/jats:styled-content>\n , (f) autologous blood\u2010derived products (\n ABDP<\/jats:styled-content>\n ), (g) cell therapy (\n CT<\/jats:styled-content>\n h), (h) recombinant morphogenic protein\u20102 (rhBMP\u20102) and (i)\n SS<\/jats:styled-content>\n alone. Quantitative analyses for different\n ARP<\/jats:styled-content>\n modalities, all of which involved socket grafting with a bone substitute, were feasible for a subset of clinical and radiographic outcomes. The results of a pooled quantitative analysis revealed that\n ARP<\/jats:styled-content>\n via socket grafting (\n ARP<\/jats:styled-content>\n \u2010\n SG<\/jats:styled-content>\n ), as compared to tooth extraction alone, prevents horizontal (\n M<\/jats:italic>\n \u00a0=\u00a01.99\u00a0mm; 95% CI 1.54\u20132.44;\n p<\/jats:italic>\n \u00a0<\u00a00.00001), vertical mid\u2010buccal (\n M<\/jats:italic>\n \u00a0=\u00a01.72\u00a0mm; 95% CI 0.96\u20132.48;\n p<\/jats:italic>\n \u00a0<\u00a00.00001) and vertical mid\u2010lingual (\n M<\/jats:italic>\n \u00a0=\u00a01.16\u00a0mm; 95%\n CI<\/jats:styled-content>\n 0.81\u20131.52;\n p<\/jats:italic>\n \u00a0<\u00a00.00001) bone resorption. Whether there is a superior\n ARP<\/jats:styled-content>\n or\n SS<\/jats:styled-content>\n approach could not be determined on the basis of the selected evidence. However, the application of particulate xenogenic or allogenic materials covered with an absorbable collagen membrane or a rapidly absorbable collagen sponge was associated with the most favourable outcomes in terms of horizontal ridge preservation. A specific quantitative analysis showed that sites presenting a buccal bone thickness >1.0\u00a0mm exhibited more favourable ridge preservation outcomes (difference between\n ARP<\/jats:styled-content>\n [\n AG<\/jats:styled-content>\n \u00a0+\u00a0\n SS<\/jats:styled-content>\n ] and control\u00a0=\u00a03.2\u00a0mm), as compared to sites with a thinner buccal wall (difference between\n ARP<\/jats:styled-content>\n [\n AG<\/jats:styled-content>\n \u00a0+\u00a0\n SS<\/jats:styled-content>\n ] and control\u00a0=\u00a01.29\u00a0mm). The effect of other local and systemic factors could not be assessed as part of the quantitative analyses.\n PROM<\/jats:styled-content>\n s were comparable between the experimental and the control group in two studies involving the use of\n ABDP<\/jats:styled-content>\n . The effect of other\n ARP<\/jats:styled-content>\n modalities on\n PROM<\/jats:styled-content>\n s could not be investigated, as these outcomes were not reported in any other clinical trial included in this study.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Alveolar ridge preservation is an effective therapy to attenuate the dimensional reduction of the alveolar ridge that normally takes place after tooth extraction.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jcpe.13057","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T08:24:24Z","timestamp":1547022264000},"page":"195-223","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":434,"title":["Effect of alveolar ridge preservation interventions following tooth extraction: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5763-0201","authenticated-orcid":false,"given":"Gustavo","family":"Avila\u2010Ortiz","sequence":"first","affiliation":[{"name":"Department of Periodontics University of Iowa Iowa City Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2838-1015","authenticated-orcid":false,"given":"Leandro","family":"Chambrone","sequence":"additional","affiliation":[{"name":"Department of Periodontics University of Iowa Iowa City Iowa"},{"name":"School of Dentistry Ibirapuera University S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4574-3671","authenticated-orcid":false,"given":"Fabio","family":"Vignoletti","sequence":"additional","affiliation":[{"name":"Department of Periodontology Universidad Complutense de Madrid Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2011.117001"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2165\/00019053-200624010-00001"},{"key":"e_1_2_9_4_1","first-page":"902","article-title":"Clinical and histologic healing of human extraction sockets filled with calcium sulfate","volume":"24","author":"Aimetti M.","year":"2009","journal-title":"International Journal of Oral and Maxillofacial Implants"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prosdent.2018.03.003"},{"key":"e_1_2_9_6_1","first-page":"121","article-title":"The influence of platelet\u2010rich plasma on the healing of extraction sockets: An explorative randomised clinical trial","volume":"3","author":"Alissa R.","year":"2010","journal-title":"European Journal of Oral Implantology"},{"key":"e_1_2_9_7_1","first-page":"411","article-title":"Implant site development by orthodontic forced extraction: A preliminary study","volume":"27","author":"Amato F.","year":"2012","journal-title":"International Journal of Oral and Maxillofacial Implants"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12366"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00642.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.6.1015"},{"issue":"5","key":"e_1_2_9_11_1","first-page":"CD010176","article-title":"Interventions for replacing missing teeth: Alveolar ridge preservation techniques for dental implant site development","volume":"28","author":"Atieh M. 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