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The mouse fibroblast cell line (L929) and pre\u2010osteoblast cell line (MC3T3\u2010E1) were subjected to cyclic tensile\/compressive stress and inflammatory stimuli (lipopolysaccharide from <jats:italic>Escherichia coli<\/jats:italic>) to verify in vivo results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Severe bone resorption was observed by microCT scanning in OE with <jats:italic>P.g<\/jats:italic> group, when compared to OE only and <jats:italic>P.g<\/jats:italic> only groups. Mechanical stress caused by OE activated the Hippo\u2010YAP pathway in periodontal tissues and upregulated the expression of JNK\/AP\u20101. OE with <jats:italic>P.g<\/jats:italic> further promoted the expression of YAP and JNK\/AP1, leading to the upregulation of the JNK\/AP\u20101 related inflammatory cytokines TNF\u2010\u03b1 and IL6. Similar results were obtained when osteoblasts were subjected to mechanical stress in vitro.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study demonstrated that periodontitis with TO caused severe inflammation\u2010induced bone resorption. Activation of YAP and upregulation of JNK\/AP\u20101 induced by TO potentially aggravated the symptoms of PD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13065","type":"journal-article","created":{"date-parts":[[2019,1,10]],"date-time":"2019-01-10T19:11:46Z","timestamp":1547147506000},"page":"438-447","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Traumatic occlusion aggravates bone loss during periodontitis and activates Hippo\u2010YAP pathway"],"prefix":"10.1111","volume":"46","author":[{"given":"Weiyi","family":"Pan","sequence":"first","affiliation":[{"name":"The State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases Department of Prosthodontics West China Hospital of Stomatology Sichuan University  Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yang","sequence":"additional","affiliation":[{"name":"The State Key Laboratory of 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