{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T12:42:55Z","timestamp":1783946575861,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T00:00:00Z","timestamp":1550534400000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Institut Straumann AG"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>An acute phase response is induced after non\u2010surgical periodontal treatment (<jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>). The main aim of this study was to compare acute phase (24\u2010hr) and medium\u2010term (3\u2010months) inflammation and clinical outcomes after <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content> with or without application of enamel matrix derivative (<jats:styled-content style=\"fixed-case\">EMD<\/jats:styled-content>) in sites with probing pocket depth (<jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content>)\u00a0\u2265\u00a06\u00a0mm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010eight periodontitis\u2010affected subjects were randomized to <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">EMD<\/jats:styled-content>. Periodontal parameters were recorded at baseline and 3\u00a0months. Serum samples were collected at baseline, 1 and 90\u00a0days after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both treatments triggered an intense acute inflammation on day 1, which regressed to baseline values at 3\u00a0months. D\u2010dimer and cystatin C levels did not show sharp increases in <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">EMD<\/jats:styled-content> group 24\u00a0hr after treatment, compared to <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>. Significant difference between groups was observed for D\u2010dimer (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). <jats:styled-content style=\"fixed-case\">EMD<\/jats:styled-content> application was also associated with better periodontal healing as shown by greater <jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content> reduction and clinical attachment level gain in sites with <jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content>\u00a0\u2265\u00a06\u00a0mm, and higher number of cases with no residual <jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content>\u00a0\u2265\u00a06\u00a0mm (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05) at 3\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">EMD<\/jats:styled-content> application after non\u2010SRP resulted in lower fibrinolysis, and better periodontal healing of deep pockets. These initial observations warrant further investigations on the potential to modulate both local and systemic outcomes of non\u2010SRP. <jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>03544931<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13074","type":"journal-article","created":{"date-parts":[[2019,1,21]],"date-time":"2019-01-21T10:28:50Z","timestamp":1548066530000},"page":"231-240","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Enamel matrix derivative stabilizes blood clot and improves clinical healing in deep pockets after flapless periodontal therapy: A Randomized Clinical Trial"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8780-7306","authenticated-orcid":false,"given":"Filippo","family":"Graziani","sequence":"first","affiliation":[{"name":"Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine University of Pisa  Pisa 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