{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:21:44Z","timestamp":1783012904720,"version":"3.54.6"},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T00:00:00Z","timestamp":1551225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate whether there was an association between chronic periodontitis (CP) and reduced respiratory function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A group of dentate 58\u2010 to 72\u2010year\u2010old men in Northern Ireland had a comprehensive periodontal examination. Parallel to the periodontal examination, participants completed questionnaires gathering information on their medical history, social circumstances, demographic background and tobacco use. A physical examination assessed anthropometric measures. Fasting blood samples were obtained and analysed for high\u2010sensitivity C\u2010reactive protein (hs\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>). Spirometry measures were performed using a wedge bellows spirometer (Vitalograph S Model). The primary outcome variable of interest was the percentage predicted forced expiratory volume in one\u2010second (% predicted<jats:styled-content style=\"fixed-case\">FEV<\/jats:styled-content><jats:sub>1<\/jats:sub>). Analysis included multiple linear regression with adjustment for various confounders and a regression\u2010based mediation analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1,380 men were included in the analysis. The mean age was 63.7\u00a0years (<jats:italic>SD<\/jats:italic>3.0). Multiple linear regression analysis showed that a doubling in mean clinical attachment loss (<jats:styled-content style=\"fixed-case\">CAL<\/jats:styled-content>) equated to a \u22123.33% (95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: \u22124.80, \u22121.86),<jats:italic>p\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001 change in % predicted<jats:styled-content style=\"fixed-case\">FEV<\/jats:styled-content><jats:sub>1<\/jats:sub>after adjustment for all other potential confounding variables. Systemic inflammation, as measured by hs\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>, only accounted for a minor mediating pathway effect (9%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this homogenous group of dentate men, CP was significantly associated with a reduced respiratory function.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13076","type":"journal-article","created":{"date-parts":[[2019,2,3]],"date-time":"2019-02-03T11:08:28Z","timestamp":1549192108000},"page":"266-275","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Chronic periodontitis and reduced respiratory function"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8783-8089","authenticated-orcid":false,"given":"Lewis","family":"Winning","sequence":"first","affiliation":[{"name":"Centre for Public Health School of Medicine Dentistry and Biomedical Sciences Queen's University Belfast Belfast UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher C.","family":"Patterson","sequence":"additional","affiliation":[{"name":"Centre for Public Health School of Medicine Dentistry and Biomedical Sciences Queen's University Belfast Belfast UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathy M.","family":"Cullen","sequence":"additional","affiliation":[{"name":"Centre for Medical Education School of Medicine Dentistry and Biomedical Sciences Queen's University Belfast Belfast UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Kee","sequence":"additional","affiliation":[{"name":"Centre for Public Health School of Medicine Dentistry and Biomedical Sciences Queen's University Belfast Belfast UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard J.","family":"Linden","sequence":"additional","affiliation":[{"name":"Centre for Public Health School of Medicine Dentistry and Biomedical Sciences Queen's University Belfast Belfast UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2011.100638"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.8.1237"},{"key":"e_1_2_9_4_1","first-page":"244","article-title":"Potential role of periodontal infection in respiratory diseases \u2010 a review","volume":"6","author":"Bansal M.","year":"2013","journal-title":"Journal of Medicine and Life"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-3514.51.6.1173"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.3.1239"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/128.4.694"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2016.150682"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12605"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2012.00457.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00009811"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.111.5.1266"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1997.68.12.1194"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200704-553CC"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S127802"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12392"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00109112"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.1.9"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyp163"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.52.9.820"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.120399"},{"issue":"14","key":"e_1_2_9_22_1","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1902\/jop.2013.1340010","article-title":"Periodontal systemic associations: Review of the evidence","volume":"40","author":"Linden G. 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