{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T23:23:24Z","timestamp":1792452204404,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T00:00:00Z","timestamp":1552953600000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This systematic review of randomized controlled trials (<jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>s) aims to answer to the following question: \u201cIn patients undergoing dental implant placement, which is the best antibiotic prophylaxis protocol to prevent early failures?\u201d<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> SCOPUS<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> CENTRAL<\/jats:styled-content> and Web of Knowledge electronic databases were searched in duplicate for <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>s up to July 2017. Additional relevant literature was identified through (i) handsearching on both relevant journals and reference lists, and (ii) searching in databases for grey literature. A network meta\u2010analysis (<jats:styled-content style=\"fixed-case\">NMA<\/jats:styled-content>) was conducted, and the probability that each protocol is the \u201cBest\u201d was estimated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>s were included, with a total of 1,693 participants. Due to the few events reported, it was not possible to conduct a <jats:styled-content style=\"fixed-case\">NMA<\/jats:styled-content> for adverse events, therefore it was conducted only for implant failures (<jats:styled-content style=\"fixed-case\">IF<\/jats:styled-content>). The protocol with the highest probability (32.5%) of being the \u201cBest\u201d one to prevent <jats:styled-content style=\"fixed-case\">IF<\/jats:styled-content> was the single dose of 3\u00a0g of amoxicillin administered 1\u00a0hr pre\u2010operatively. Even if the single pre\u2010operative dose of 2\u00a0g of amoxicillin is the most used, it achieved only a probability of 0.2% to be the \u201cBest\u201d one.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Basing on the available <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>s, the use of antibiotic prophylaxis is protective against early implant failures. Whenever an antibiotic prophylaxis is needed, there is still insufficient evidence to confidently recommend a specific dosage. The use of post\u2010operative courses does not seem however to be justified by the available literature. Prospero registration number: <jats:styled-content style=\"fixed-case\">CRD<\/jats:styled-content>42015029708.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13080","type":"journal-article","created":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T11:21:09Z","timestamp":1549538469000},"page":"382-395","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":96,"title":["Antibiotic prophylaxis at dental implant placement: Which is the best protocol? A systematic review and network meta\u2010analysis"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5646-083X","authenticated-orcid":false,"given":"Mario","family":"Romandini","sequence":"first","affiliation":[{"name":"Department of Medical, Oral and Biotechnological Sciences University of Chieti\u2010Pescara  Chieti Italy"},{"name":"Institute of Dentistry and Maxillofacial, Surgery Fondazione Policlinico Universitario A. 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