{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T12:50:05Z","timestamp":1777121405206,"version":"3.51.4"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T00:00:00Z","timestamp":1552953600000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"University Complutense of Madrid and Dentaid S.A.","award":["58\/2015"],"award-info":[{"award-number":["58\/2015"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the efficacy of a 0.03% chlorhexidine and 0.05% cetylpyridinium chloride mouth rinse, as an adjunct to professionally and patient\u2010administered mechanical plaque removal, in the treatment of peri\u2010implant mucositis (PiM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Patients displaying PiM in, at least, one implant were included in this randomized, double\u2010blinded, clinical trial. Subjects received professional prophylaxis (baseline and 6\u00a0months) and were instructed to regular oral hygiene practices and to rinse, twice daily, with the test or placebo mouth rinses, during one year. Clinical, radiographic and microbiological outcomes were evaluated at baseline, 6 and 12\u00a0months. Disease resolution was defined as absence of bleeding on probing (<jats:styled-content style=\"fixed-case\">BOP<\/jats:styled-content>). Data were analysed by repeated measures <jats:styled-content style=\"fixed-case\">ANOVA<\/jats:styled-content>, Student's t and chi\u2010square tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010four patients were included and 46 attended the final visit (22 in control and 24 in test group). In the test group, there was a 24.49% greater reduction in <jats:styled-content style=\"fixed-case\">BOP<\/jats:styled-content> at the buccal sites (95% confidence interval [3.65\u201345.34%]; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.002) than in controls. About 58.3% of test implants and 50% controls showed healthy peri\u2010implant tissues at final visit (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The use of the test mouth rinse demonstrated some adjunctive benefits in the treatment of PiM. Complete disease resolution could not be achieved in every case.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13088","type":"journal-article","created":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T06:25:22Z","timestamp":1550557522000},"page":"342-353","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Clinical effects of the adjunctive use of a 0.03% chlorhexidine and 0.05% cetylpyridinium chloride mouth rinse in the management of peri\u2010implant diseases: A randomized clinical trial"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7632-1690","authenticated-orcid":false,"given":"Alberto","family":"Pulcini","sequence":"first","affiliation":[{"name":"ETEP (Etiology and Therapy of Periodontal Diseases) Research Group University Complutense  Madrid 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