{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:08:52Z","timestamp":1791644932634,"version":"4.3.4"},"reference-count":58,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,5,20]],"date-time":"2019-05-20T00:00:00Z","timestamp":1558310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007194","name":"Wenzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["Y20140704"],"award-info":[{"award-number":["Y20140704"]}],"id":[{"id":"10.13039\/501100007194","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007194","name":"Wenzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["Y20160051"],"award-info":[{"award-number":["Y20160051"]}],"id":[{"id":"10.13039\/501100007194","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81802230"],"award-info":[{"award-number":["81802230"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870777"],"award-info":[{"award-number":["81870777"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81500817"],"award-info":[{"award-number":["81500817"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2019,6]]},"abstract":"Abstract<\/jats:title>\n \n Aim<\/jats:title>\n \n Oxidative stress (\n OS<\/jats:styled-content>\n ) biomarkers have been detected in saliva and gingival crevicular fluid (\n GCF<\/jats:styled-content>\n ) during chronic periodontitis (\n CP<\/jats:styled-content>\n ) progression; however, the relationship between\n OS<\/jats:styled-content>\n biomarkers and\n CP<\/jats:styled-content>\n progression remains elusive. The purpose of this meta\u2010analysis is to investigate the relationship between local\n OS<\/jats:styled-content>\n biomarkers and\n CP<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This review was conducted through a systematic search from three databases. Studies on\n CP<\/jats:styled-content>\n participants were included as an experimental group, and studies on periodontally healthy (\n PH<\/jats:styled-content>\n ) participants were included as a control. Mean effects were expressed as standardized mean difference with their associated 95% confidence intervals.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n From a total of 2,972 articles, 32 articles fulfilled the inclusion criteria. We found a significant decrease of total antioxidant capacity and a significant increase of malondialdehyde (\n MDA<\/jats:styled-content>\n ), nitric oxide, total oxidant status (\n TOS<\/jats:styled-content>\n ), and 8\u2010hydroxy\u2010deoxyguanosine levels in the saliva of\n CP<\/jats:styled-content>\n patients. Moreover, we also found an elevation of\n MDA<\/jats:styled-content>\n level in\n GCF<\/jats:styled-content>\n of\n CP<\/jats:styled-content>\n group when compared with the\n PH<\/jats:styled-content>\n group. There were no significant differences of salivary and\n GCF<\/jats:styled-content>\n superoxide dismutase levels, salivary glutathione peroxidase level, and\n GCF TOS<\/jats:styled-content>\n level between two groups. However, a high heterogeneity was observed among evaluated studies.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Despite the limitations of this study, the result of our meta\u2010analysis supported the rationale that there was a direct link between\n CP<\/jats:styled-content>\n and\n OS<\/jats:styled-content>\n \u2010related biomarkers\u2019 levels in the local site, indicating the important role of\n OS<\/jats:styled-content>\n in the onset and development of\n CP<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jcpe.13112","type":"journal-article","created":{"date-parts":[[2019,4,16]],"date-time":"2019-04-16T03:22:13Z","timestamp":1555384933000},"page":"608-622","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":247,"title":["Oxidative stress\u2010related biomarkers in saliva and gingival crevicular fluid associated with chronic periodontitis: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"46","author":[{"given":"Mengmeng","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Prosthodontics School and Hospital of Stomatology Wenzhou Medical University Wenzhou China"},{"name":"Institute of Stomatology School and Hospital of Stomatology Wenzhou Medical University Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjin","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics School and Hospital of Stomatology Wenzhou Medical University Wenzhou China"},{"name":"Institute of Stomatology School and Hospital of Stomatology Wenzhou Medical University Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shufan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Oral Maxillofacial Surgery School and Hospital of Stomatology Wenzhou Medical University Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixi","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics School and Hospital of Stomatology Wenzhou Medical University Wenzhou China"},{"name":"Institute of Stomatology School and Hospital of Stomatology Wenzhou Medical University Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics School and Hospital of Stomatology Wenzhou Medical University Wenzhou China"},{"name":"Institute of Stomatology School and Hospital of Stomatology Wenzhou Medical University Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xumin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics School and Hospital of Stomatology Wenzhou Medical University Wenzhou China"},{"name":"Institute of Stomatology School and Hospital of Stomatology Wenzhou Medical University Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Sun","sequence":"additional","affiliation":[{"name":"Institute of Stomatology School and Hospital of Stomatology Wenzhou Medical University Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixin","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics School and Hospital of Stomatology Wenzhou Medical University Wenzhou China"},{"name":"Institute of Stomatology School and Hospital of Stomatology Wenzhou Medical University Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"He","sequence":"additional","affiliation":[{"name":"Protein Section Laboratory of Metabolism Center for Cancer Research National Cancer Institute National Institutes of Health Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubo","family":"Hou","sequence":"additional","affiliation":[{"name":"Institute of Stomatology School and Hospital of Stomatology Wenzhou Medical University Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Institute of Stomatology School and Hospital of Stomatology Wenzhou Medical University Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaozhen","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics School and Hospital of Stomatology Wenzhou Medical University Wenzhou China"},{"name":"Institute of Stomatology School and Hospital of Stomatology Wenzhou Medical University Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfeng","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics School and Hospital of Stomatology Wenzhou Medical University Wenzhou China"},{"name":"Institute of Stomatology School and Hospital of Stomatology Wenzhou Medical University Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4522-2769","authenticated-orcid":false,"given":"Shengbin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics School and Hospital of Stomatology Wenzhou Medical University Wenzhou China"},{"name":"Institute of Stomatology School and Hospital of Stomatology Wenzhou Medical University Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2017.00189"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2007.01091.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.080218"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00669.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/653537"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjdr.2014.04.002"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12368"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2001.028006565.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2013.130012"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2014.130654"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.15537\/smj.2015.7.11954"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1697415"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060469"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2006.00178.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/137.3.657"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.12.143"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12993"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.120195"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(86)90046-2"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034516629112"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.21592"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/216964"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/adj.12294"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2003.03104.x"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-008-0202-z"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2014.140338"},{"key":"e_1_2_8_29_1","volume-title":"Cochrane handbook for systematic reviews of interventions version 5.1.0","author":"Higgins J. P. T.","year":"2011"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-5-13"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.5455\/oams.040714.or.069"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/9421019"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2009.06.006"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/931083"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016357.2013.795659"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2015.150353"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-016-2029-3"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12088"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-016-1984-z"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2015.11.014"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1997.tb00189.x"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/7916578"},{"key":"e_1_2_8_43_1","first-page":"180","article-title":"Oxidative stress in periodontitis: A critical link to cardiovascular disease","volume":"22","author":"Ps D.","year":"2011","journal-title":"Biomedical Research"},{"key":"e_1_2_8_44_1","unstructured":"Rostom A. Dube C. &Cranney A.(2004).Celiac disease.Rockville MD:Agency for Healthcare Research and Quality (US); (Evidence Reports\/Technology Assessments No. 104.) Appendix D. Quality Assessment Forms. Retrieved fromhttp:\/\/www.ncbi.nlm.nih.gov\/books\/NBK35156."},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.2005.00215.x"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/215430"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.38"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12711"},{"key":"e_1_2_8_49_1","first-page":"1223","article-title":"Comparison of the salivary and the serum nitric oxide levels in chronic and aggressive periodontitis: A biochemical study","volume":"7","author":"Sundar N. M.","year":"2013","journal-title":"Journal of Clinical and Diagnostic Research"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2012.01468.x"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2011.100618"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2013.130066"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.11607\/prd.2079"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2005.00818.x"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2015.150293"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.5051\/jpis.2013.43.5.215"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1834-7819.2009.01123.x"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12175"},{"key":"e_1_2_8_59_1","first-page":"97","article-title":"Total antioxidant capacity and total oxidant status in saliva of periodontitis patients in relation to bacterial load","volume":"5","author":"Zhang T.","year":"2015","journal-title":"Frontiers in Cellular and Infection Microbiology"}],"container-title":["Journal of Clinical Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcpe.13112","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpe.13112","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcpe.13112","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpe.13112","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T16:15:02Z","timestamp":1694362502000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcpe.13112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,20]]},"references-count":58,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1111\/jcpe.13112"],"URL":"https:\/\/doi.org\/10.1111\/jcpe.13112","archive":["Portico"],"relation":{},"ISSN":["0303-6979","1600-051X"],"issn-type":[{"value":"0303-6979","type":"print"},{"value":"1600-051X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,20]]},"assertion":[{"value":"2018-10-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}