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The following parameters were assessed in 34 <jats:styled-content style=\"fixed-case\">ACPA<\/jats:styled-content>\u2010positive (<jats:styled-content style=\"fixed-case\">ACPA<\/jats:styled-content>+) and 65 <jats:styled-content style=\"fixed-case\">ACPA<\/jats:styled-content>\u2010negative (<jats:styled-content style=\"fixed-case\">ACPA<\/jats:styled-content>\u2212) subjects: gingival index (<jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content>), plaque index (<jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content>), probing depth (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>), bleeding on probing (<jats:styled-content style=\"fixed-case\">BOP<\/jats:styled-content>) and clinical attachment level (<jats:styled-content style=\"fixed-case\">CAL<\/jats:styled-content>). We compared the two groups using conditional logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In <jats:styled-content style=\"fixed-case\">ACPA<\/jats:styled-content>+ individuals, the mean,<jats:styled-content style=\"fixed-case\"> PD<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> BOP<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> CAL<\/jats:styled-content> and number of sites per person with <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\u00a0&gt;\u00a04\u00a0mm and <jats:styled-content style=\"fixed-case\">BOP<\/jats:styled-content> were significantly higher compared to\u00a0the <jats:styled-content style=\"fixed-case\">ACPA<\/jats:styled-content>\u2010 group. All <jats:styled-content style=\"fixed-case\">ACPA<\/jats:styled-content>+ subjects had periodontitis: 44.1% presenting moderate and 47.1% severe periodontitis. <jats:styled-content style=\"fixed-case\">ACPA<\/jats:styled-content>\u2010 subjects had mainly mild (30.8%) and moderate (27%) periodontitis, differences being significantly different for both moderate periodontitis (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.001) and severe periodontitis (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). In multivariable analyses, <jats:styled-content style=\"fixed-case\">ACPA<\/jats:styled-content> status (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.04) and age (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.002) were significantly and\u00a0independently associated with periodontal conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>High prevalence and severity of periodontitis in <jats:styled-content style=\"fixed-case\">FDR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> was associated with seropositivity to <jats:styled-content style=\"fixed-case\">ACPA<\/jats:styled-content>s. This further strengthens the hypothesis that periodontitis may be a risk factor in the development of <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13117","type":"journal-article","created":{"date-parts":[[2019,4,26]],"date-time":"2019-04-26T08:36:12Z","timestamp":1556267772000},"page":"690-698","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Periodontal status correlates with anti\u2010citrullinated protein antibodies in first\u2010degree relatives of individuals with rheumatoid arthritis"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6757-0452","authenticated-orcid":false,"given":"Lucie","family":"Loutan","sequence":"first","affiliation":[{"name":"Division of Periodontology University Clinic of Dental Medicine University of Geneva Geneva 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