{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T22:59:02Z","timestamp":1788303542917,"version":"build-2803163510"},"reference-count":85,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T00:00:00Z","timestamp":1559260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The aim of this network meta\u2010analysis (NMA) was to compare the efficacy of different oral hygiene products for chemical biofilm control, in 6\u2010month home\u2010use, randomized clinical trials (RCTs), in terms of changes in gingival index (GI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>Six\u2010month RCTs assessing GI were identified and screened for inclusion. Relevant information was extracted, and quality and potential risk of bias were estimated. Mean differences between baseline and end were calculated to obtain standardized mean differences (SMDs). NMA protocols were applied to assess direct and indirect comparisons among products using L\u00f6e &amp; Silness GI, modified GI and gingival severity index.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifty\u2010three papers were included, 19 studies for mouth rinses, 32 for dentifrices, comprising data from 5,775 and 2,682 subjects, respectively. When ranking treatments, similar results were observed for all tested dentifrices, with the lowest effect observed for sanguinarine and baking soda. For mouth rinses, essential oils, triclosan\u2013copolymer, chlorhexidine (at concentrations\u00a0\u2265\u00a00.10%) and cetylpyridinium chloride (&gt;0.05%) demonstrated the greatest effect.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although NMA revealed significant differences when comparing placebo versus some active agents, when comparing among active agents, no differences were found for dentifrices, while mouth rinses containing essential oils showed the greatest effect on GI scores.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.13127","type":"journal-article","created":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T17:26:07Z","timestamp":1557163567000},"page":"723-739","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":90,"title":["Efficacy of adjunctive anti\u2010plaque chemical agents in managing gingivitis: A systematic review and network meta\u2010analyses"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3129-1416","authenticated-orcid":false,"given":"Elena","family":"Figuero","sequence":"first","affiliation":[{"name":"ETEP (Etiology and Therapy of Periodontal Diseases) Research Group University Complutense Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5554-2777","authenticated-orcid":false,"given":"David","family":"Herrera","sequence":"additional","affiliation":[{"name":"ETEP (Etiology and Therapy of Periodontal Diseases) Research Group University Complutense Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6428-6755","authenticated-orcid":false,"given":"Aurelio","family":"Tob\u00edas","sequence":"additional","affiliation":[{"name":"Institute of Environmental Assessment and Water Research (IDAEA) Spanish Council for Scientific Research (CSIC) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3634-0360","authenticated-orcid":false,"given":"Jorge","family":"Serrano","sequence":"additional","affiliation":[{"name":"ETEP (Etiology and Therapy of Periodontal Diseases) Research Group University Complutense Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4585-8997","authenticated-orcid":false,"given":"Silvia","family":"Rold\u00e1n","sequence":"additional","affiliation":[{"name":"ETEP (Etiology and Therapy of Periodontal Diseases) Research Group University Complutense Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Escribano","sequence":"additional","affiliation":[{"name":"ETEP (Etiology and Therapy of Periodontal Diseases) Research Group University Complutense Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3997-6900","authenticated-orcid":false,"given":"Conchita","family":"Mart\u00edn","sequence":"additional","affiliation":[{"name":"BIOCRAN (Craniofacial Biology) Research Group University Complutense Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.01013.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-5037.2010.00478.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2007.01103.x"},{"key":"e_1_2_8_5_1","first-page":"59","article-title":"The clinical efficacy of Colgate Total Plus Whitening Toothpaste containing a special grade of silica and Colgate Total Fresh Stripe Toothpaste in the control of plaque and gingivitis: A six\u2010month clinical study","volume":"13","author":"Allen D. 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