{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T03:55:36Z","timestamp":1788062136666,"version":"build-2784847793"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,7,19]],"date-time":"2019-07-19T00:00:00Z","timestamp":1563494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004704","name":"National Research Council of Thailand","doi-asserted-by":"publisher","award":["2552\u201054"],"award-info":[{"award-number":["2552\u201054"]}],"id":[{"id":"10.13039\/501100004704","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004704","name":"National Research Council of Thailand","doi-asserted-by":"publisher","award":["2553\u2010138"],"award-info":[{"award-number":["2553\u2010138"]}],"id":[{"id":"10.13039\/501100004704","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This cross\u2010sectional study examined the associations between periodontitis and the serum cardiac biomarkers\u2014soluble ST2 (sST2) and C\u2010reactive protein (CRP)\u2014in systemically healthy adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Periodontitis severity was determined using mean probing depth (PD) or clinical attachment level (CAL) and a categorical variable (no\/mild, moderate, or severe). Oral hygiene was evaluated using plaque scores. Regression analyses assessed the associations between periodontal variables and sST2 or CRP levels, adjusting for age, sex, smoking, body mass index, systolic blood pressure, fasting plasma glucose, and high\u2010density or low\u2010density lipoprotein cholesterol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study population comprised 799 individuals, aged 50\u201373\u00a0years. After multivariable adjustment, greater mean PD\/CAL, severe periodontitis, and poor oral hygiene were associated with elevated sST2 and CRP levels (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). Greater mean PD or CAL was associated with increased odds of having sST2 in the top quintile (&gt;22.7\u00a0\u03bcg\/L) (odds ratio [OR] [95% confidence interval (CI)]: 1.7 [1.1\u20132.4] and 1.3 [1.1\u20131.7], respectively) and CRP\u00a0&gt;\u00a03\u00a0mg\/L (OR: 1.5 [1.1\u20132.1] and 1.3 [1.0\u20131.5], respectively). Individuals with poor oral hygiene were more likely to have sST2\u00a0&gt;\u00a022.7\u00a0\u03bcg\/L (OR: 2.0 [1.0\u20134.0]) and CRP\u00a0&gt;\u00a03\u00a0mg\/L (OR: 2.0 [1.1\u20133.5]), compared to those with good oral hygiene.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Periodontitis and poor oral hygiene were associated with elevated serum sST2 and CRP levels.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13149","type":"journal-article","created":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T20:33:12Z","timestamp":1558729992000},"page":"809-818","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Periodontitis is associated with elevated serum levels of cardiac biomarkers\u2014Soluble ST2 and C\u2010reactive protein"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6781-797X","authenticated-orcid":false,"given":"Kitti","family":"Torrungruang","sequence":"first","affiliation":[{"name":"Department of Microbiology, Faculty of Dentistry Chulalongkorn University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dissayawadee","family":"Katudat","sequence":"additional","affiliation":[{"name":"Bangkok Hospital Pattaya Chonburi Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rangsini","family":"Mahanonda","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Faculty of Dentistry Chulalongkorn University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piyamitr","family":"Sritara","sequence":"additional","affiliation":[{"name":"Cardiology Division, Department of Internal Medicine, Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artit","family":"Udomsak","sequence":"additional","affiliation":[{"name":"Medical and Health Department Electricity Generating Authority of Thailand Nonthaburi Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.09.027"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-004-2184-x"},{"key":"e_1_2_8_4_1","article-title":"A comparison of soluble ST2 and high sensitivity C\u2010reactive protein for prediction of cardiovascular mortality in the Electricity Generating Authority of Thailand cohort study","volume":"35","author":"Chanyavanich P.","year":"2014","journal-title":"European Heart 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