{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T23:32:37Z","timestamp":1776382357840,"version":"3.51.2"},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T00:00:00Z","timestamp":1569369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>It is unclear whether patients with specific subgingival microbiological profiles benefit more from adjunctive systemic antibiotics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To answer the question: \u201cWhat is the clinical benefit in periodontitis patients taking adjunctive systemic antimicrobials to non\u2010surgical therapy, depending on pre\u2010treatment detection of periodontopathogenic bacteria?\u201d<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>A search was conducted in four electronic databases for randomized controlled trials reporting clinical outcomes following adjunctive antibiotic therapy for patients divided by baseline microbiological profiles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The initial search resulted in 643 papers, reduced to five after screening and author contact. Four of these studies were suitable for a fixed effects two\u2010stage individual participant data meta\u2010analysis adjusted for baseline data. Collectively, adjunctive amoxicillin and metronidazole yielded superior clinical results (measured as reduction of PPDs) compared to placebo. No significant differences were detected for the effect of adjunctive antibiotics by the detection of <jats:italic>Aggregatibacter actinomycetemcomitans<\/jats:italic> on PPDs\u00a0\u2265\u00a05\u00a0mm (WMD\u00a0=\u00a01.16, 95% CI [\u22125.37, 7.68], <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a037.8%) or other clinical outcomes. All included studies had low risk of bias.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There is no evidence to suggest that baseline detection of periodontopathogenic bacteria should be used as criterion for prescribing adjunctive antibiotics, although only limited information on microbial data and specific antimicrobials was available for analysis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13164","type":"journal-article","created":{"date-parts":[[2019,6,29]],"date-time":"2019-06-29T04:44:36Z","timestamp":1561783476000},"page":"999-1012","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Empirical or microbiologically guided systemic antimicrobials as adjuncts to non\u2010surgical periodontal therapy? A systematic review"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7750-5010","authenticated-orcid":false,"given":"Luigi","family":"Nibali","sequence":"first","affiliation":[{"name":"Centre for Oral Immunobiology and Regenerative Medicine and Centre for Oral Clinical Research, Institute of Dentistry Queen Mary University London (QMUL) London UK"},{"name":"Periodontology Unit Centre for Host-Microbiome Interactions, Faculty of Dentistry Oral &amp; Craniofacial Sciences, King's College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasiliki P.","family":"Koidou","sequence":"additional","affiliation":[{"name":"Centre for Oral Immunobiology and Regenerative Medicine and Centre for Oral Clinical Research, Institute of Dentistry Queen Mary University London (QMUL) London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Hamborg","sequence":"additional","affiliation":[{"name":"Pragmatic Clinical Trials Unit Queen Mary University London (QMUL) London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikos","family":"Donos","sequence":"additional","affiliation":[{"name":"Centre for Oral Immunobiology and Regenerative Medicine and Centre for Oral Clinical Research, Institute of Dentistry Queen Mary University London (QMUL) London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,9,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2017.03.011"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jicd.12197"},{"issue":"1","key":"e_1_2_8_4_1","first-page":"1","article-title":"Periodontosis: Case report with long\u2010term follow\u2010up","volume":"1","author":"Baer P. 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