{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:10:44Z","timestamp":1789495844311,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,8,25]],"date-time":"2019-08-25T00:00:00Z","timestamp":1566691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the superiority of coronally advanced flaps (CAFs) when used in combination with a xenogeneic collagen matrix (CMX) for root coverage of multiple adjacent gingival recessions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Participants with at least 2 upper adjacent teeth exhibiting gingival recession depth \u22652\u00a0mm were recruited and randomized to CAF with (test) or without (control) CMX, respectively. Mean and complete root coverage, amount of keratinized tissue (KTw), gingival thickness (GThick) and patient\u2010reported outcomes (PROMs) were recorded at baseline, 3, 6 and 12\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010four patients providing 61 gingival recessions were analysed. After 1\u00a0year, gingival recession depth decreased from 2.3\u00a0\u00b1\u00a00.7 to 0.3\u00a0\u00b1\u00a00.4\u00a0mm in the CAF\u00a0+\u00a0CMX group (2.0\u00a0\u00b1\u00a00.8\u00a0mm meanRC) and from 2.6\u00a0\u00b1\u00a01.0 to 0.6\u00a0\u00b1\u00a00.3\u00a0mm in the control group (2.0\u00a0\u00b1\u00a01.1\u00a0mm meanRC). No difference was observed between the two groups (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.2023). Nineteen (63%) of the test and 16 (52%) of control defects showed complete root coverage (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.4919). GThick greatly increased in the test group (0.5\u00a0mm; 0.2\u20130.8\u00a0mm, 95% CI; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.0057). No difference between the two groups was observed for KTw (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.5668) and PROMs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>At 1\u00a0year, CAF\u00a0+\u00a0CMX provided similar root coverage to CAF alone, but a significant increase in gingival thickness.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13168","type":"journal-article","created":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T07:53:24Z","timestamp":1562831604000},"page":"1013-1023","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Adjunctive benefit of a xenogenic collagen matrix associated with coronally advanced flap for the treatment of multiple gingival recessions: A superiority, assessor\u2010blind, randomized clinical trial"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9090-0624","authenticated-orcid":false,"given":"Roberto","family":"Rotundo","sequence":"first","affiliation":[{"name":"Honorary Associate Professor in Periodontology UCL Eastman Dental Institute London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Genzano","sequence":"additional","affiliation":[{"name":"Private Practice Prato Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divya","family":"Patel","sequence":"additional","affiliation":[{"name":"Specialist Trainee UCL Eastman Dental Institute London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8654-935X","authenticated-orcid":false,"given":"Francesco","family":"D'Aiuto","sequence":"additional","affiliation":[{"name":"Chair and Honorary Consultant in Periodontology UCL Eastman Dental Institute London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8770-4622","authenticated-orcid":false,"given":"Michele","family":"Nieri","sequence":"additional","affiliation":[{"name":"Department of Surgery and Translational Medicine University of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.090122"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12211"},{"issue":"4","key":"e_1_2_7_4_1","first-page":"229","article-title":"Problems and proposals for recording gingivitis and plaque","volume":"25","author":"Ainamo J.","year":"1975","journal-title":"International Dental 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