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Gingival crevicular fluid repository samples from participants with and without periodontal disease (using Gingival Index [GI] and Bleeding on Probing [BOP] parameters on dental examination) were tested for concentration levels of inflammatory biomarkers. Associations were assessed using Wilcoxon test and Spearman correlation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For perinatal HIV youth (<jats:italic>n<\/jats:italic>\u00a0=\u00a0129), the markers consistently elevated (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05) in sites with GI \u22652 and in sites with BOP were interleukin\u20101\u03b2, 6 and 13, macrophage inflammatory protein\u20101\u03b1 and metalloproteinase\u20109. Serum tumour necrosis factor\u2010\u03b1 and soluble CD14 were positively correlated with a summary count of elevated cytokines. No associations were seen among HIV\u2010uninfected subjects (<jats:italic>n<\/jats:italic>\u00a0=\u00a071).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The association of oral biomarkers of inflammation with clinical indicators of periodontal inflammation and systemic immune activation suggests that perinatal HIV\u2010infected youth may be at higher risk for developing significant periodontal disease, associated with tooth loss and HIV progression. More frequent dental care of this group is needed to prevent potential periodontal progression.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13179","type":"journal-article","created":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T09:34:30Z","timestamp":1565084070000},"page":"1072-1082","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Biomarkers of oral inflammation in perinatally HIV\u2010infected and perinatally HIV\u2010exposed, uninfected youth"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6317-5233","authenticated-orcid":false,"given":"Anna\u2010Barbara","family":"Moscicki","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Adolescent and Young Adult Medicine University of California Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzy\u2010Jyun","family":"Yao","sequence":"additional","affiliation":[{"name":"Center for Biostatistics in AIDS Research (CBAR) Harvard T.H. Chan School of Public Health Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan S.","family":"Russell","sequence":"additional","affiliation":[{"name":"Center for Biostatistics in AIDS Research (CBAR) Harvard T.H. Chan School of Public Health Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sepideh","family":"Farhat","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Adolescent Medicine University of California San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Scott","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Adolescent Medicine University of California San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry","family":"Magpantay","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordana","family":"Halec","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA Los Angeles 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