{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T15:31:01Z","timestamp":1784561461147,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,10,7]],"date-time":"2019-10-07T00:00:00Z","timestamp":1570406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2014HP019"],"award-info":[{"award-number":["ZR2014HP019"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the effect of bone morphogenetic protein 2 (BMP\u20102) incorporated biomimetic calcium phosphate (BMP\u20102\/BioCaP) in conjunction with barrier membrane on periodontal regeneration in chronic periodontitis experimental model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Chronic periodontitis experimental model with critical\u2010sized supra\u2010alveolar defects was created in 15 dogs\u2019 mandibles. After the initial periodontal therapy, the defects were randomly assigned to the following groups: (a) control; (b) barrier membrane; (c) deproteinized bovine bone mineral\u00a0+\u00a0barrier membrane; (d) BioCaP\u00a0+\u00a0barrier membrane and (e) BMP\u20102\/BioCaP\u00a0+\u00a0barrier membrane (6 quadrants with 18 teeth per group). Eight weeks later, clinical examinations, micro\u2010CT, and histomorphometric analyses were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Clinical examinations, including plaque index, bleeding index, and probing depth, were similar for all groups. In contrast, the clinical attachment loss was significantly lower in defects grafted with BMP\u20102\/BioCaP and barrier membrane. The micro\u2010CT results showed that the height of mineralized tissue in defects grafted with BMP\u20102\/BioCaP and barrier membrane was significantly higher. For histometric analysis, the defects grafted with BMP\u20102\/BioCaP and barrier membrane exhibited significantly more connective tissue height, new cementum height, new bone height and area, as well as less down\u2010growth of junctional epithelium.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>BMP\u20102\/BioCaP could be a promising bone substitute for periodontal regeneration.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13195","type":"journal-article","created":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T20:33:36Z","timestamp":1568406816000},"page":"1254-1263","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Periodontal regeneration using bone morphogenetic protein 2 incorporated biomimetic calcium phosphate in conjunction with barrier membrane: A pre\u2010clinical study in dogs"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5035-4817","authenticated-orcid":false,"given":"Lingfei","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Oral Implantology Yantai Stomatological Hospital Yantai China"},{"name":"Department of Oral Implantology and Prosthetic Dentistry Academic Center for Dentistry Amsterdam (ACTA) Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Teng","sequence":"additional","affiliation":[{"name":"Department of Oral Implantology and Prosthetic Dentistry Academic Center for Dentistry Amsterdam (ACTA) Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liquan","family":"Deng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Stomatology School of Stomatology Zhejiang Chinese Medical University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gangfeng","family":"Liu","sequence":"additional","affiliation":[{"name":"Faculty of Stomatology Binzhou Medical University Yantai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyin","family":"Luan","sequence":"additional","affiliation":[{"name":"Faculty of Stomatology Binzhou Medical University Yantai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Jiang","sequence":"additional","affiliation":[{"name":"Faculty of Stomatology Binzhou Medical University Yantai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonghao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Oral Implantology Yantai Stomatological Hospital Yantai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuelian","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Oral Implantology and Prosthetic Dentistry Academic Center for Dentistry Amsterdam (ACTA) Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2007.05.023"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e3182982f8e"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12048"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034514544301"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2002.73.8.925"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345970760080801"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1997.68.2.103"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.12.1688"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2004.00508.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034515618887"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12283"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep41800"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.36398"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034511435260"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2010.01281.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034509349748"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-014-1323-1"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.080568"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.12.1808"},{"key":"e_1_2_9_21_1","first-page":"299","article-title":"The critical size defect as an experimental model for craniomandibulofacial nonunions","author":"Schmitz J. 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