{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T14:06:47Z","timestamp":1789654007204,"version":"4.0.0"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,10,16]],"date-time":"2019-10-16T00:00:00Z","timestamp":1571184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To compare 10\u2010month histological and immunohistological outcomes after soft tissue thickening around teeth with a porcine collagen matrix (CM) versus a subepithelial connective tissue graft (SCTG).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>In eight beagle dogs, soft tissue thickening of the buccal gingiva of upper canines was performed with the SCTG or the CM. Connective tissue thickness (CTT) was histomorphometrically measured in the augmented regions. The augmented connective tissues were also histologically characterized and the collagen I and vascular endothelial growth factor (VEGF) expressions immunohistologically quantified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CTT significantly differed between groups (SCTG: 1.32\u00a0mm\u00a0\u00b1\u00a00.44\u00a0mm; CM: 1.06\u00a0mm\u00a0\u00b1\u00a00.27\u00a0mm;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.008). Descriptive histological analyses revealed mature connective tissue that did not differ between groups. Immunohistological quantification of collagen I and VEGF expressions in the connective tissue also revealed no significant inter\u2010group differences (collagen I: SCTG, 32.64%\u00a0\u00b1\u00a07.09% vs. CM, 30.57%\u00a0\u00b1\u00a07.83%; VEGF: SCTG, 39.06%\u00a0\u00b1\u00a07.27% vs. CM, 37.15%\u00a0\u00b1\u00a09.80%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SCTG is superior to CM with regard to CTT in this experimental model. The CM and the SCTG lead to comparable connective tissue quality ten months after connective tissue thickening.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.13196","type":"journal-article","created":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T05:20:36Z","timestamp":1568352036000},"page":"1273-1281","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Gingiva thickening with a porcine collagen matrix in a preclinical dog model: Histological outcomes"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9028-5139","authenticated-orcid":false,"given":"Christian M.","family":"Schmitt","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University of Erlangen\u2010Nuremberg Erlangen Germany"},{"name":"Private Practice Prof. Schlegel and Colleagues Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl Andreas","family":"Schlegel","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University of Erlangen\u2010Nuremberg Erlangen Germany"},{"name":"Private Practice Prof. Schlegel and Colleagues Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Gammel","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University of Erlangen\u2010Nuremberg Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Moest","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University of Erlangen\u2010Nuremberg Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,16]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"87","article-title":"Use of a new cross\u2010linked collagen membrane for the treatment of peri\u2010implant dehiscence defects: A randomised controlled double\u2010blinded clinical trial","volume":"4","author":"Annen B. 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