{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:39:14Z","timestamp":1792035554932,"version":"4.4.0"},"reference-count":43,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T00:00:00Z","timestamp":1573171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess, retrospectively, whether older age has an impact on implant osseointegration when compared with younger age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All patients \u226565\u00a0years old at implant installation, in an university setting over a time\u2010period of 11.5\u00a0years, with complete anamnestic data and follow\u2010up until prosthetic restoration were included, and any early implant loss (EIL; i.e. lack of osseointegration prior to or at the time\u2010point of prosthetic restoration) was recorded. Further, one implant, from each of the elderly patients, was attempted matched to one implant in a younger patient (35 to &lt;55\u00a0years old at implant installation) from the same clinic based on (a) gender, (b) implant region, (c) smoking status and (d) bone grafting prior to\/simultaneously with implant installation. The potential impact of various local and systemic factors on EIL in the entire elderly population, and in the matched elderly and younger patient group was statistically assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four hundred forty\u2010four patients \u226565\u00a0years old (range 65.1\u201391.3; 56.8% female) receiving 1,517 implants were identified; 10 patients had one EIL each (implant\/patient level: 0.66\/2.25%). Splitting this patient cohort additionally into four age groups [65\u201369.9 (<jats:italic>n<\/jats:italic>\u00a0=\u00a0213), 70\u201374.9 (<jats:italic>n<\/jats:italic>\u00a0=\u00a0111), 75\u201379.9 (<jats:italic>n<\/jats:italic>\u00a0=\u00a080) and \u226580 (<jats:italic>n<\/jats:italic>\u00a0=\u00a040)], EIL was on the implant level 0.41, 0.83, 0.34 and 2.26%, respectively, (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.102) and on the patient level 1.41, 2.70, 1.25 and 7.50%, respectively, (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.104); multilevel analysis showed weak evidence of association of increasing age with higher EIL rate (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.090). Matching was possible in 347 cases, and 5 (1.44%) and 9 (2.59%) EIL in the elderly and younger patients, respectively, were observed (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.280). EIL could not be associated with any systemic condition or medication intake.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Elderly patients \u226565\u00a0years old presented a similarly low EIL rate as younger patients 35 to &lt;55\u00a0years old, while patients \u226580\u00a0years old may have a slight tendency for a higher EIL rate. Hence, ageing does not seem to compromise osseointegration, and if at all, then only slightly and at a later stage of life.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13199","type":"journal-article","created":{"date-parts":[[2019,9,17]],"date-time":"2019-09-17T15:00:18Z","timestamp":1568732418000},"page":"1282-1293","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["How old is old for implant therapy in terms of early implant losses?"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8279-7943","authenticated-orcid":false,"given":"Kristina","family":"Bertl","sequence":"first","affiliation":[{"name":"Department of Periodontology Faculty of Odontology University of Malm\u00f6 Malm\u00f6 Sweden"},{"name":"Division of Oral Surgery University Clinic of Dentistry Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Ebner","sequence":"additional","affiliation":[{"name":"Division of Oral Surgery University Clinic of Dentistry Medical University of Vienna Vienna Austria"},{"name":"Comprehensive Center Unit University Clinic of Dentistry Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Knibbe","sequence":"additional","affiliation":[{"name":"Division of Oral Surgery University Clinic of Dentistry Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Pandis","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Dentofacial Orthopedics School of Dental Medicine University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Kuchler","sequence":"additional","affiliation":[{"name":"Division of Oral Surgery University Clinic of Dentistry Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Ulm","sequence":"additional","affiliation":[{"name":"Division of Oral Surgery University Clinic of Dentistry Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8161-3754","authenticated-orcid":false,"given":"Andreas","family":"Stavropoulos","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Odontology University of Malm\u00f6 Malm\u00f6 Sweden"},{"name":"Division of Conservative Dentistry and Periodontology University Clinic of Dentistry Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12506"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2007.01077.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12477"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12133"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.29.s3.12.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12179"},{"key":"e_1_2_7_8_1","first-page":"470","article-title":"The effects of age, jaw site, and bone condition on oral implant outcomes","volume":"11","author":"Bryant S. R.","year":"1998","journal-title":"The International Journal of Prosthodontics"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034513504947"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000048929"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034516646098"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.5662"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.5305"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034514563077"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1741-2358.2009.00348.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2004.tb00035.x"},{"key":"e_1_2_7_17_1","first-page":"101","article-title":"Does antibiotic prophylaxis at implant placement decrease early implant failures? A Cochrane systematic review","volume":"3","author":"Esposito M.","year":"2010","journal-title":"European Journal of Oral Implantology"},{"key":"e_1_2_7_18_1","volume-title":"Population structure and ageing","author":"Eurostat","year":"2018"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-016-0300-9"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.21815\/JDE.017.080"},{"key":"e_1_2_7_21_1","first-page":"155","article-title":"A systematic review of survival of single implants as presented in longitudinal studies with a follow\u2010up of at least 10 years","volume":"9","author":"Hjalmarsson L.","year":"2016","journal-title":"European Journal of Oral Implantology"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2009.01517.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12539"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2012.02547.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13268"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2010.00329.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.11607\/ijp.3780"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/ID.0000000000000386"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034513509630"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.2334\/josnusd.48.1"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2009.10.002"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prosdent.2015.07.020"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.16.e514"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2012.02546.x"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01750.x"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2017.08.003"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12166"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/joor.12465"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(10)80390-8"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12898"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4636(199701)34:1<1::AID-JBM1>3.0.CO;2-V"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12890"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12455"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034514549378"}],"container-title":["Journal of Clinical Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpe.13199","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcpe.13199","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpe.13199","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T12:17:05Z","timestamp":1693743425000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcpe.13199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,8]]},"references-count":43,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1111\/jcpe.13199"],"URL":"https:\/\/doi.org\/10.1111\/jcpe.13199","archive":["Portico"],"relation":{},"ISSN":["0303-6979","1600-051X"],"issn-type":[{"value":"0303-6979","type":"print"},{"value":"1600-051X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,8]]},"assertion":[{"value":"2019-02-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}