{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T08:04:22Z","timestamp":1787731462347,"version":"build-2784847793"},"reference-count":66,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T00:00:00Z","timestamp":1573689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004357","name":"Procter and Gamble","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004357","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To estimate gingivitis effects of a bioavailable gluconate chelated 0.454% stannous fluoride (SnF<jats:sub>2<\/jats:sub>) family of dentifrices in adult subjects versus positive (triclosan) and negative (NaF or MFP) controls when used \u22643\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>A meta\u2010analysis evaluated bioavailable gluconate chelated SnF<jats:sub>2<\/jats:sub> dentifrices versus a negative or positive control for gingival bleeding.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 18 randomized controlled trials (RCTs) with 2,890 subjects assessing SnF<jats:sub>2<\/jats:sub> paste versus a negative or positive control, the average number of bleeding sites was reduced by 51% and 31%, respectively. The average change (95% CI) in number of bleeding sites was \u221216.3 (\u221227.8, \u22124.9) versus the negative control and \u22123.6 (\u22125.4, \u22121.8) versus the positive control. Subjects with localized or generalized gingivitis had 3.7 times better odds (95% CI [2.8, 5.0]) of shifting to generally healthy using SnF<jats:sub>2<\/jats:sub> versus a negative control and 2.8 times better odds (95% CI [2.1, 3.9]) of shifting to generally healthy using SnF<jats:sub>2<\/jats:sub> versus a positive control. The individual study risk of bias was deemed to be low in all categories of bias.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This meta\u2010analysis demonstrates significant gingivitis benefits of bioavailable SnF<jats:sub>2<\/jats:sub> dentifrices when used \u22643\u00a0months versus positive (triclosan) and negative (NaF or MFP) controls.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13203","type":"journal-article","created":{"date-parts":[[2019,9,28]],"date-time":"2019-09-28T20:13:59Z","timestamp":1569701639000},"page":"1205-1216","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["The effects of bioavailable gluconate chelated stannous fluoride dentifrice on gingival bleeding: Meta\u2010analysis of eighteen randomized controlled trials"],"prefix":"10.1111","volume":"46","author":[{"given":"Aaron","family":"Biesbrock","sequence":"first","affiliation":[{"name":"The Procter &amp; Gamble Company Mason OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"He","sequence":"additional","affiliation":[{"name":"The Procter &amp; Gamble Company Mason OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe","family":"DiGennaro","sequence":"additional","affiliation":[{"name":"The Procter &amp; Gamble Company Mason OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanshu","family":"Zou","sequence":"additional","affiliation":[{"name":"The Procter &amp; Gamble Company Mason OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dave","family":"Ramsey","sequence":"additional","affiliation":[{"name":"The Procter &amp; Gamble Company Mason OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franklin","family":"Garcia\u2010Godoy","sequence":"additional","affiliation":[{"name":"College of Dentistry The University of Tennessee Health Science Center Memphis TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,14]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"13A","article-title":"Randomized controlled trial evaluating concurrent gingivitis and stain effects of a two\u2010step dentifrice\/gel sequence","volume":"31","author":"Amini P.","year":"2018","journal-title":"American Journal of Dentistry"},{"key":"e_1_2_8_3_1","volume-title":"A randomized clinical trial to evaluate a daily two\u2010step dentifrice and gel system in the prevention of stain, plaque and calculus following a dental prophylaxis","author":"Amini P.","year":"2014"},{"key":"e_1_2_8_4_1","first-page":"Abstract 0320","article-title":"Gingivitis response comparing SnF2\/H2O2 and KNO3 daily use whitening products","volume":"95","author":"Amini P.","year":"2016","journal-title":"Journal of Dental Research"},{"issue":"1","key":"e_1_2_8_5_1","first-page":"12","article-title":"Antigingivitis efficacy of a stabilized stannous fluoride\/sodium hexametaphosphate dentifrice in subjects previously nonresponsive to a triclosan\/copolymer dentifrice","volume":"26","author":"Archila L.","year":"2005","journal-title":"Compendium of Continuing Education in Dentistry"},{"key":"e_1_2_8_6_1","first-page":"111","article-title":"A comparison of the efficacy of a triclosan\/copolymer\/sodium fluoride dentifrice, a stannous fluoride\/sodium hexametaphosphate\/zinc lactate dentifrice, and a sodium fluoride dentifrice for the control of established supragingival plaque and gingivitis: A six\u2010week clinical study","volume":"21","author":"Ayad F.","year":"2010","journal-title":"Journal of Clinical Dentistry"},{"key":"e_1_2_8_7_1","first-page":"Abstract 294","article-title":"Plaque imaging comparison of two\u2010step SnF2\/H2O2 dentifrices versus triclosan dentifrice","volume":"94","author":"Barker M. 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