{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:15:49Z","timestamp":1789193749311,"version":"build-2803163510"},"reference-count":70,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,11,26]],"date-time":"2019-11-26T00:00:00Z","timestamp":1574726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The purpose of this randomized controlled clinical study was to evaluate the effect of non\u2010surgical mechanical periodontal therapy on the inflammatory status and severity of psoriasis in subjects with psoriasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>The study population consisted of 92 periodontitis patients with psoriasis vulgaris suffering from an untreated periodontal disease. Two randomized groups were formed from these patients: immediate periodontal therapy (test group,<jats:italic>n<\/jats:italic>\u00a0=\u00a046) and delayed periodontal therapy (control group,<jats:italic>n<\/jats:italic>\u00a0=\u00a046). Periodontal clinical measures, on salivary interleukin 2, interleukin 6 and secretory immunoglobulin A levels and the Psoriasis Area and Severity Index (PASI) scores were evaluated at baseline and on the 8th week in control and test groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eight weeks after completion of non\u2010surgical periodontal therapy (test group) or initial examination (control group), a significant decrease was observed in interleukin 2, interleukin 6 level and in PASI score, whereas a significant increase was observed in secretory immunoglobulin A levels in the test group (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Within the limits of this study, the results suggest that effective periodontal therapy improves the psoriasis condition in patients afflicted by both diseases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13205","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T05:44:23Z","timestamp":1569908663000},"page":"193-201","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Effects of non\u2010surgical periodontal therapy on inflammatory markers of psoriasis: A randomized controlled trial"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8126-585X","authenticated-orcid":false,"given":"Fatma","family":"Ucan Yarkac","sequence":"first","affiliation":[{"name":"Faculty of Dentistry, Periodontology Necmettin Erbakan University Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2999-2691","authenticated-orcid":false,"given":"Atiye","family":"Ogrum","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Dermatology and Venereology Gaziosmanpasa University Tokat Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6662-3185","authenticated-orcid":false,"given":"Ozge","family":"Gokturk","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Periodontology Bolu Abant Izzet Baysal University Bolu Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12748"},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1358\/dot.1999.35.12.564038","article-title":"The pathophysiological role of cytokines in psoriasis","volume":"35","author":"Asadullah K.","year":"1999","journal-title":"Drugs of Today (Barcelona, Spain: 1998)"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.22260"},{"key":"e_1_2_8_5_1","first-page":"209","article-title":"Psoriasis: A review of systemic comorbidities and dental management considerations","volume":"49","author":"Brooks J. 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